体重指数与立体定向放射外科治疗难治性三叉神经痛的疗效：一项回顾性队列研究。
Body mass index and response to stereotactic radiosurgery in the treatment of refractory trigeminal neuralgia: A retrospective cohort study.
作者信息
Khattab Mohamed H, Sherry Alexander D, Kim Ellen, Anderson Joshua, Luo Guozhen, Yu Hong, Englot Dario J, Chambless Lola B, Cmelak Anthony J, Attia Albert
机构信息
Department of Radiation Oncology, Vanderbilt University Medical Center, 2220 Pierce Avenue, PRB-B1003, Nashville, TN 37232, USA.
Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
出版信息
J Radiosurg SBRT. 2020;6(4):253-261.
Stereotactic radiosurgery (SRS) is used as a noninvasive treatment option for patients with trigeminal neuralgia (TN), but the effect of obesity on pain relief post SRS, if any, is unknown. The primary goal of our study was to evaluate the association between obesity and response to SRS in patients with TN. We conducted an IRB-approved retrospective review of patients treated with SRS for TN between 2010 and 2017. Barrow Neurologic Institute (BNI) Score was assigned pre-and post-SRS to quantify pain level. Thirty-two patients (65% female) between the ages of 24 and 96 were studied with a median follow-up time of 11 months. Patients with BMI >25 were significantly less likely to have improvement in their symptoms with SRS (p = 0.005). Elevated BMI may be associated with worsened response to SRS in the treatment of TN.
立体定向放射外科手术（SRS）被用作三叉神经痛（TN）患者的一种非侵入性治疗选择，但肥胖对SRS后疼痛缓解的影响（如果有）尚不清楚。我们研究的主要目的是评估肥胖与TN患者对SRS反应之间的关联。我们对2010年至2017年间接受SRS治疗的TN患者进行了一项经机构审查委员会（IRB）批准的回顾性研究。在SRS前后采用巴罗神经学研究所（BNI）评分来量化疼痛程度。研究了32例年龄在24至96岁之间的患者（65%为女性），中位随访时间为11个月。体重指数（BMI）>25的患者通过SRS改善症状的可能性显著降低（p = 0.005）。BMI升高可能与TN治疗中对SRS的反应变差有关。
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