Hozumi Jun, Sumitani Masahiko, Matsubayashi Yoshitaka, Abe Hiroaki, Oshima Yasushi, Chikuda Hirotaka, Takeshita Katsushi, Yamada Yoshitsugu
Department of Anesthesiology and Pain Relief Center, The University of Tokyo Hospital, Tokyo 113-8655, Japan.
Department of Pain and Palliative Medicine, The University of Tokyo Hospital, Tokyo 113-8655, Japan.
Pain Res Manag. 2016;2016:2487924. doi: 10.1155/2016/2487924. Epub 2016 Mar 29.
Objectives. Overweight negatively affects musculoskeletal health; hence obesity is considered a risk factor for osteoarthritis and chronic low back pain. This was conducted to determine if obesity affects neuropathic pain, usually considered unrelated to the weight-load on the musculoskeletal system. Methods. Using a cut-off body mass index value of 25, 44 patients with neuropathic pain were grouped into a "high-BMI" group and a "normal-BMI" group. Results. The numeric rating scale of the high-BMI group was significantly higher than that of the normal-weight group (P < 0.05). The total NPSI scores were significantly higher (P < 0.01), and the paroxysmal pain and the negative symptoms were more serious in the high-BMI group than in the normal-BMI group. The high-BMI subjects also had significantly higher SF-MPQ scores (P < 0.05). However, both physical and mental health status on the SF-36 were comparable between the groups. Discussion. Neuropathic pain that did not arise from musculoskeletal damage was higher in the high-BMI patients. Paroxysmal pain was more severe, suggesting that neural damage might be aggravated by obesity-associated inflammation. These findings should have needed to be confirmed in future studies.
目的。超重会对肌肉骨骼健康产生负面影响；因此，肥胖被认为是骨关节炎和慢性腰痛的一个风险因素。本研究旨在确定肥胖是否会影响神经性疼痛，通常认为神经性疼痛与肌肉骨骼系统的体重负荷无关。方法。采用体重指数临界值25，将44例神经性疼痛患者分为“高体重指数”组和“正常体重指数”组。结果。高体重指数组的数字评分量表得分显著高于正常体重组（P < 0.05）。高体重指数组的总神经病理性疼痛量表（NPSI）得分显著更高（P < 0.01），且发作性疼痛和阴性症状比正常体重指数组更严重。高体重指数受试者的简化McGill疼痛问卷（SF-MPQ）得分也显著更高（P < 0.05）。然而，两组之间在SF-36量表上的生理和心理健康状况相当。讨论。高体重指数患者中，非肌肉骨骼损伤引起的神经性疼痛更高。发作性疼痛更严重，提示肥胖相关炎症可能会加重神经损伤。这些发现需要在未来的研究中得到证实。
