O'Brien Ciara M, Duda Joan L, Kitas George D, Veldhuijzen van Zanten Jet J C S, Metsios George S, Fenton Sally A M
School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, United Kingdom.
Department of Rheumatology, Russells Hall Hospital, Dudley Group NHS Foundation Trust, West Midlands, United Kingdom.
Mediterr J Rheumatol. 2019 Jun 29;30(2):125-134. doi: 10.31138/mjr.30.2.125. eCollection 2019 Jun.
The accurate measurement of sedentary time and physical activity in Rheumatoid Arthritis (RA) is critical to identify important health consequences and determinants of these behaviours in this patient group. However, objective methods have not been well-validated for measurement of sedentary time and physical activity in RA.
Specific objectives are to: 1) validate the ActiGraph GT3X+ accelerometer and activPAL3 against indirect calorimetry and direct observation respectively, and define RA-specific accelerometer cut-points, for measurement of sedentary time and physical activity in RA; 2) validate the RA-specific sedentary time accelerometer cut-points against the activPAL3; 3) compare sedentary time and physical activity estimates in RA, using RA-specific vs. widely-used non-RA accelerometer cut-points.
People with RA will wear an ActiGraph GT3X+, activPAL3, heart rate monitor and indirect calorimeter, whilst being video-recorded undertaking 11 activities representative of sedentary behaviour, and light and moderate intensity physical activity. People with RA will wear an ActiGraph GT3X+ and activPAL3 for 7 days to measure free-living sedentary time and physical activity.
This will be the first study to define RA-specific accelerometer cut-points, and represents the first validation of the ActiGraph accelerometer and activPAL, for measurement of sedentary time and physical activity in RA. Findings will inform future RA studies employing these devices, ensuring more valid assessment of sedentary time and physical activity in this patient group.
准确测量类风湿关节炎（RA）患者的久坐时间和身体活动对于确定该患者群体中这些行为的重要健康后果及决定因素至关重要。然而，客观方法在测量RA患者的久坐时间和身体活动方面尚未得到充分验证。
具体目标如下：1）分别对照间接量热法和直接观察法，验证ActiGraph GT3X+加速度计和activPAL3，确定用于测量RA患者久坐时间和身体活动的RA特异性加速度计切点；2）对照activPAL3验证RA特异性久坐时间加速度计切点；3）使用RA特异性与广泛使用的非RA加速度计切点，比较RA患者的久坐时间和身体活动估计值。
RA患者将佩戴ActiGraph GT3X+、activPAL3、心率监测器和间接量热计，同时进行视频记录，记录11种代表久坐行为、轻度和中度强度身体活动的活动。RA患者将佩戴ActiGraph GT3X+和activPAL3 7天，以测量日常生活中的久坐时间和身体活动。
这将是第一项确定RA特异性加速度计切点的研究，也是首次对ActiGraph加速度计和activPAL进行验证，用于测量RA患者的久坐时间和身体活动。研究结果将为未来使用这些设备的RA研究提供参考，确保对该患者群体的久坐时间和身体活动进行更有效的评估。
