O'Brien Ciara M, Duda Joan L, Kitas George D, Veldhuijzen van Zanten Jet J C S, Metsios George S, Fenton Sally A M
School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, United Kingdom.
Department of Rheumatology, Russells Hall Hospital, Dudley Group NHS Foundation Trust, West Midlands, United Kingdom.
Mediterr J Rheumatol. 2018 Jun 29;29(2):106-117. doi: 10.31138/mjr.29.2.106. eCollection 2018 Jun.
Sedentary behaviour (SB) is associated with adverse health outcomes in the general population. Replacing sedentary time with light intensity physical activity (LPA) has been linked with improvements in all-cause and cardiovascular disease mortality in adults. People with Rheumatoid Arthritis (RA) typically spend long periods of time sedentary, but the health consequences of 'too much sitting', and possible benefits of LPA, have not been fully explored in this population. Moreover, little is known regarding the determinants of these behaviours among people living with RA, and such knowledge is required for the development of effective behavioural interventions.
To examine longitudinal relationships between: 1) objectively-assessed SB/LPA with health outcomes in RA, 2) hypothesised determinants of SB/LPA with objectively-assessed SB/LPA in RA.
This longitudinal study will secure assessments at baseline (Time 1) and 6-month follow-up (Time 2) from RA patients. At both time points, physical assessments will be undertaken, and questionnaires administered to measure physical (e.g., percentage body fat, disease activity, physical function, pain) and psychological (e.g., depression, anxiety, vitality) health outcomes. Additional questionnaires will be administered to establish hypothesised determinants (i.e., psychosocial, individual differences, and physical environmental). Participants will wear the ActiGraph GT3X accelerometer and activPAL3 for 7 days to objectively measure SB and LPA.
Findings will elucidate the health correlates of SB in RA, as well as the relevance of interventions targeting reductions in SB by promoting LPA. Results will also assist in identifying intervention targets (i.e., determinants), with the potential to encourage SB change in RA.
久坐行为(SB)与普通人群的不良健康结局相关。用轻度身体活动(LPA)替代久坐时间与成年人全因死亡率和心血管疾病死亡率的改善有关。类风湿关节炎(RA)患者通常长时间久坐,但在这一人群中,“久坐过多”对健康的影响以及LPA可能带来的益处尚未得到充分研究。此外,对于RA患者这些行为的决定因素知之甚少,而此类知识对于制定有效的行为干预措施是必要的。
研究以下纵向关系:1)客观评估的RA患者的SB/LPA与健康结局之间的关系;2)假设的RA患者SB/LPA的决定因素与客观评估的SB/LPA之间的关系。
这项纵向研究将在基线(时间1)和6个月随访(时间2)时对RA患者进行评估。在两个时间点,都将进行身体评估,并发放问卷以测量身体(如体脂百分比、疾病活动度、身体功能、疼痛)和心理(如抑郁、焦虑、活力)健康结局。还将发放额外的问卷以确定假设的决定因素(即社会心理、个体差异和物理环境)。参与者将佩戴ActiGraph GT3X加速度计和activPAL3 7天,以客观测量SB和LPA。
研究结果将阐明RA患者中SB与健康的相关性,以及通过促进LPA来减少SB的干预措施的相关性。结果还将有助于确定干预目标(即决定因素),有可能促使RA患者改变久坐行为。