Bounia Konstantina A, Konstantopoulou Georgia M, Liossis Stamatis-Nick C
Patras University Hospital, Department of Internal Medicine, Division of Rheumatology, Rion, Patras, Greece.
University of Patras Medical School, Rion, Patras, Greece.
Mediterr J Rheumatol. 2019 Sep 30;30(3):190-193. doi: 10.31138/mjr.30.3.190. eCollection 2019 Sep.
A 40-year old woman with recent asymmetric arthritis and fever was evaluated in our clinic. NSAIDs were recommended, but a few days later she was admitted to our hospital because of worsening arthritis along with the appearance of new skin lesions in both feet. Although she was treated with antibiotics and high dosages of steroids, her arthritis did not improve. The skin lesions progressed from bullous initially to ulcerative pyoderma gangrenosum, so we suggested endoscopic examination of the colon which revealed Crohn's disease. The patient received I.V. treatment with infliximab resulting in a remarkable response. Some patients with Crohn's disease may present with extraintestinal manifestations well before the bowel disease is manifested and diagnosed.
一名40岁近期出现不对称性关节炎和发热的女性在我们诊所接受了评估。建议使用非甾体抗炎药，但几天后她因关节炎恶化以及双脚出现新的皮肤病变而入住我院。尽管她接受了抗生素和高剂量类固醇治疗，但其关节炎并未改善。皮肤病变最初从大疱性发展为溃疡性坏疽性脓皮病，因此我们建议对结肠进行内镜检查，结果显示为克罗恩病。该患者接受了英夫利昔单抗静脉治疗，效果显著。一些克罗恩病患者在肠道疾病表现和诊断之前可能就会出现肠外表现。
