López San Román A, Bermejo F, Aldanondo I, Carrera E, Boixeda D, Muñoz Zato E
Services of Gastroenterology, University Hospital Ramón y Cajal, Madrid, Spain.
Rev Esp Enferm Dig. 2004 Jun;96(6):420-2; 422-4. doi: 10.4321/s1130-01082004000600008.
Pyoderma gangrenosum is an extraintestinal manifestation of inflammatory bowel disease that can be therapeutically troublesome. We comment on the case of a patient with clinically inactive ulcerative colitis who progressively developed necrotic lesions on both tibial aspects of his legs, which corresponded both clinically and histologically to pyoderma gangrenosum. Treatment with steroids and azathioprine could not control this complication. A single dose of infliximab 5 mg/kg was given, achieving an impressive response of the skin lesions followed by complete healing 3 months later. Infliximab can be useful in the management of refractory extraintestinal manifestations of inflammatory bowel disease.
坏疽性脓皮病是炎症性肠病的一种肠外表现，治疗起来可能比较棘手。我们对一名临床缓解期的溃疡性结肠炎患者的病例进行评论，该患者双下肢胫部逐渐出现坏死性皮损，临床及组织学表现均符合坏疽性脓皮病。使用类固醇和硫唑嘌呤治疗无法控制这一并发症。给予单剂量英夫利昔单抗5mg/kg后，皮损迅速出现显著反应，3个月后完全愈合。英夫利昔单抗在治疗炎症性肠病难治性肠外表现方面可能有效。
