van Es L A, Blok A P, Schoenfield L, Glassock R J
Kidney Int. 1977 Feb;11(2):106-15. doi: 10.1038/ki.1977.15.
The pathogenesis of chronic membranous glomerulonephritis induced in rats by passive immunization with heterologous antibodies to rat renal tubular epithelial (RTE) antigens was investigated. This model is designated as "passive Heymann nephritis" (PHN) in order to contrast it with classical Heymann nephritis induced by active immunization with homologous RTE in adjuvant. A single i.v. injection of heterologous (rabbit) antibody to RTE evoked chronic proteinuria after a latent period of one to three days. The onset of proteinuria was accompanied by the granular deposition of rabbit IgG and rat beta1C globulin along the glomerular capillary wall. Renal isografts developed PHN only when transplanted within the first three days following injection of the heterologous anti-RTE antibodies. The data suggest that the heterologous antibodies form immune complexes with RTE antigens preexisting in the circulation, and these complexes subsequently deposit in the glomerular capillary walls. Chronic proteinuria is then perpetuated by a host reaction to the foreign protein in the deposits (i.e., rabbit IgG), in a fashion analogous to that seen in the autologus phase of nephrotoxic serum nephritis. These studies indicate that continued glomerular deposition of preformed circulating immune complexes may not always be a requisite for the perpetuation of glomerular injury in immune complex disease.
通过用针对大鼠肾小管上皮（RTE）抗原的异源抗体进行被动免疫诱导大鼠慢性膜性肾小球肾炎的发病机制进行了研究。该模型被命名为“被动海曼肾炎”（PHN），以便与通过在佐剂中用同源RTE进行主动免疫诱导的经典海曼肾炎形成对比。静脉内单次注射针对RTE的异源（兔）抗体，在1至3天的潜伏期后诱发慢性蛋白尿。蛋白尿的出现伴随着兔IgG和大鼠β1C球蛋白沿肾小球毛细血管壁的颗粒状沉积。肾同基因移植仅在注射异源抗RTE抗体后的头三天内移植时才会发生PHN。数据表明，异源抗体与循环中预先存在的RTE抗原形成免疫复合物，这些复合物随后沉积在肾小球毛细血管壁上。然后，宿主对沉积物中的外来蛋白质（即兔IgG）的反应使慢性蛋白尿持续存在，其方式类似于在肾毒性血清肾炎的自身阶段所见。这些研究表明，预先形成的循环免疫复合物在肾小球中的持续沉积可能并不总是免疫复合物疾病中肾小球损伤持续存在的必要条件。
