Ford P M, Kosatka I
Immunology. 1981 Jul;43(3):433-9.
The intravenous injection into mice of small amounts of heat-aggregated bovine serum albumin (BSA) results in deposition of BSA within the glomerulus. Injection of rabbit anti-BSA antibody at a time when all circulating BSA has been cleared results in in situ formation of BSA anti-BSA immune complexes with fixation of mouse C3. Subsequent injection of passively-prepared immune complexes gives much enhanced deposition of immune material when compared with mice given immune complexes alone. This paper shows that this is an antigen-specific phenomenon and not a result of non-specific trapping by damaged glomeruli. The implications of these observations on the pathogenesis of immune complex glomerulonephritis are discussed.
给小鼠静脉注射少量热聚集牛血清白蛋白（BSA）会导致BSA在肾小球内沉积。当所有循环中的BSA已被清除时注射兔抗BSA抗体，会导致原位形成BSA-抗BSA免疫复合物并固定小鼠C3。与单独给予免疫复合物的小鼠相比，随后注射被动制备的免疫复合物会使免疫物质的沉积显著增强。本文表明这是一种抗原特异性现象，而非受损肾小球非特异性捕获的结果。文中讨论了这些观察结果对免疫复合物性肾小球肾炎发病机制的影响。
