生物碱、类黄酮、多酚可能是龙葵具有强效抗关节炎作用的原因。
Alkaloids, flavonoids, polyphenols might be responsible for potent antiarthritic effect of Solanum nigrum.
机构信息
Laboratory of Cardiovascular Research and Integrative Pharmacology, College of Pharmacy, University of Sargodha, Sargodha 40100, Pakistan.
出版信息
J Tradit Chin Med. 2019 Oct;39(5):632-641.
OBJECTIVE
To evaluate in vitro and in vivo antiarthritic potential of Solanum nigrum (S. nigrum).
METHODS
Aqueous methanolic (70∶30) extract of S. nigrum was prepared. The in vitro antiarthritic effect was evaluated in terms of its inhibition of protein denaturation and membrane stabilization. While, formaldehyde, complete Freund's adjuvant (CFA) and Collagen induced arthritis rat models were used to study in vivo antiarthritic activities of S. nigrum at dose level of 200, 400 and 800 mg/kg.
RESULTS
The extract exhibited inhibition of protein denaturation and protected red blood cell by stabilizing the membranes in a concentration dependent manner, with maximum effect attained at 800 μg/mL. Moreover, there was a marked reduction in paw edema observed in extract treated animals, when compared to arthritic control animals in all in vivo models and 800 mg/kg dose got maximum reduction of paw edema. In CFA and collagen models, plant extract restored body weight, hematologic parameters, radiographic and histopathologic alterations towards normal.
CONCLUSION
It could be concluded that S. nigrum holds antiarthritic potential, supporting its traditional use in treatment of rheumatoid arthritis.
目的
评估龙葵的体外和体内抗关节炎潜力。
方法
制备龙葵的水-甲醇（70∶30）提取物。根据其抑制蛋白质变性和膜稳定化作用来评估体外抗关节炎作用。同时，使用甲醛、完全弗氏佐剂（CFA）和胶原诱导性关节炎大鼠模型，在 200、400 和 800 mg/kg 剂量水平下研究龙葵的体内抗关节炎活性。
结果
该提取物表现出抑制蛋白质变性和通过稳定膜的方式保护红细胞，具有浓度依赖性，在 800 μg/mL 时达到最大效果。此外，与所有体内模型中的关节炎对照动物相比，在提取物处理的动物中观察到爪肿胀明显减少，800 mg/kg 剂量的提取物可最大程度地减少爪肿胀。在 CFA 和胶原模型中，植物提取物使体重、血液学参数、影像学和组织病理学改变恢复正常。
结论
可以得出结论，龙葵具有抗关节炎潜力，支持其在治疗类风湿性关节炎中的传统用途。
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