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皂角苷通过线粒体介导的途径诱导体外 SGC-7901 人胃癌细胞凋亡。

Solasonine induces apoptosis of the SGC-7901 human gastric cancer cell line in vitro via the mitochondria-mediated pathway.

机构信息

School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China.

Department of Integrated Traditional and Western Medicine, Fujian Medical University Cancer Hospital & Fujian Provincial Cancer Hospital, Fuzhou, China.

出版信息

J Cell Mol Med. 2022 Jun;26(12):3387-3395. doi: 10.1111/jcmm.17343. Epub 2022 May 7.

DOI:10.1111/jcmm.17343
PMID:35524577
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9189336/
Abstract

Solasonine, a steroidal glycoalkaloid isolated from the herbal plant Solanum nigrum Linn., has shown active against multiple human cancers; however, there is little knowledge on the activity of solasonine against gastric cancer until now. This study aimed to examine the effect of solasonine on the biological behaviours of human gastric cancer SGC-7901 cells. The results showed that solasonine suppressed SGC-7901 cell proliferation in a dose-dependent manner. Solasonine treatment mainly induced the cell cycle arrest at G2 phase in SGC-7901 cells. Treatment with solasonine resulted in significant down-regulation of Bcl-2 and Caspase-3 protein expression and reduced Bax and Bcl-xL protein expression in SGC-7901 cells. Solasonine shows a comparable inhibitory effect on the proliferation of human gastric cancer SGC-7901 cells with cisplatin, and solasonine induces of SGC-7901 cell apoptosis through triggering the endoplasmic reticulum stress pathway and the mitochondrial pathway. Our data indicate that solasonine may be a promising agent for the treatment of gastric cancer.

摘要

龙葵碱，一种从草药龙葵中分离得到的甾体糖苷生物碱，已被证明对多种人类癌症具有活性；然而，直到现在，关于龙葵碱对胃癌的活性知之甚少。本研究旨在探讨龙葵碱对人胃癌 SGC-7901 细胞生物学行为的影响。结果表明，龙葵碱呈剂量依赖性抑制 SGC-7901 细胞增殖。龙葵碱处理主要诱导 SGC-7901 细胞在 G2 期停滞。龙葵碱处理导致 SGC-7901 细胞中 Bcl-2 和 Caspase-3 蛋白表达下调，Bax 和 Bcl-xL 蛋白表达减少。龙葵碱对人胃癌 SGC-7901 细胞的增殖具有与顺铂相当的抑制作用，并且龙葵碱通过触发内质网应激途径和线粒体途径诱导 SGC-7901 细胞凋亡。我们的数据表明，龙葵碱可能是治疗胃癌的一种有前途的药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/046e/9189336/06d5e066241c/JCMM-26-3387-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/046e/9189336/d181be70cac5/JCMM-26-3387-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/046e/9189336/78a720fd7e14/JCMM-26-3387-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/046e/9189336/312814f85083/JCMM-26-3387-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/046e/9189336/0fdbd61287c0/JCMM-26-3387-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/046e/9189336/06d5e066241c/JCMM-26-3387-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/046e/9189336/d181be70cac5/JCMM-26-3387-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/046e/9189336/78a720fd7e14/JCMM-26-3387-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/046e/9189336/312814f85083/JCMM-26-3387-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/046e/9189336/0fdbd61287c0/JCMM-26-3387-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/046e/9189336/06d5e066241c/JCMM-26-3387-g005.jpg

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本文引用的文献

1
Gastric cancer: a comprehensive review of current and future treatment strategies.胃癌：当前和未来治疗策略的综合综述。
Cancer Metastasis Rev. 2020 Dec;39(4):1179-1203. doi: 10.1007/s10555-020-09925-3. Epub 2020 Sep 7.
2
Advances in the treatment of gastric cancer.胃癌治疗的新进展。
Curr Opin Gastroenterol. 2020 Nov;36(6):525-529. doi: 10.1097/MOG.0000000000000679.
3
Gastric cancer.胃癌。
Drug Des Devel Ther. 2024 Jun 21;18:2485-2529. doi: 10.2147/DDDT.S472178. eCollection 2024.
4
Molecular Mechanism Analysis of the Effect of Hederagenin Combined with L-OHP on Chemosensitivity of AGS/L-OHP Based on Network Pharmacology.基于网络药理学的常春藤皂苷元联合奥沙利铂对AGS/L-OHP细胞化疗敏感性影响的分子机制分析
Curr Comput Aided Drug Des. 2024 Jan 11. doi: 10.2174/0115734099270389240104050955.
5
Active components of Solanum nigrum and their antitumor effects: a literature review.龙葵的活性成分及其抗肿瘤作用：文献综述
Front Oncol. 2023 Dec 19;13:1329957. doi: 10.3389/fonc.2023.1329957. eCollection 2023.
6
Identification of ACHE as the hub gene targeting solasonine associated with non-small cell lung cancer (NSCLC) using integrated bioinformatics analysis.利用综合生物信息学分析鉴定 ACHE 为与非小细胞肺癌（NSCLC）相关的龙葵素作用靶点的枢纽基因。
PeerJ. 2023 Oct 10;11:e16195. doi: 10.7717/peerj.16195. eCollection 2023.
7
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4
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6
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10
Bioactive glycoalkaloides isolated from Solanum melongena fruit peels with potential anticancer properties against hepatocellular carcinoma cells.从茄子果皮中分离得到的具有潜在抗癌活性的生物活性糖生物碱，可抑制肝癌细胞。
Sci Rep. 2019 Feb 11;9(1):1746. doi: 10.1038/s41598-018-36089-6.