Emerg Infect Dis. 2020 Apr;26(4):667-674. doi: 10.3201/eid2604.191031.
Shigellosis outbreaks caused by Shigella with decreased susceptibility to azithromycin (DSA-Shigella) among men who have sex with men (MSM) have been reported worldwide. We describe sexual health indicators and antimicrobial drug resistance for shigellosis cases in Minnesota, USA. We analyzed a sample of isolates received during 2012-2015 and cross-referenced cases with the Minnesota Department of Health Sexually Transmitted Disease Database to ascertain patients' HIV status and recent chlamydia, gonorrhea, and syphilis infections. Of 691 Shigella isolates, 46 (7%) were DSA-Shigella; 91% of DSA-Shigella patients were men, of whom 60% were living with HIV. Among men, those with DSA-Shigella infection had greater odds of living with HIV, identifying as MSM, or having a recent diagnosis of a sexually transmitted disease. DSA-Shigella was associated with MSM, HIV infection, and recent sexually transmitted disease. To decrease spread of DSA-Shigella, interventions targeted at communities at high risk are needed.
志贺氏菌对阿奇霉素的敏感性降低（DSA-志贺氏菌）引起的志贺氏菌病爆发在男男性行为者（MSM）中已在全球范围内报道。我们描述了美国明尼苏达州志贺氏菌病病例的性健康指标和抗微生物药物耐药性。我们分析了 2012-2015 年期间收到的分离株样本，并与明尼苏达州卫生部门的性传播疾病数据库交叉引用病例，以确定患者的 HIV 状况以及最近的衣原体、淋病和梅毒感染情况。在 691 株志贺氏菌分离株中，有 46 株（7%）是 DSA-志贺氏菌；91%的 DSA-志贺氏菌患者为男性，其中 60%为 HIV 感染者。在男性中，感染 DSA-志贺氏菌的患者更有可能携带 HIV，被认定为 MSM，或最近被诊断患有性传播疾病。DSA-志贺氏菌与 MSM、HIV 感染和最近的性传播疾病有关。为了减少 DSA-志贺氏菌的传播，需要针对高危社区的干预措施。
