Chartspiroton，一种来源于药用植物内生菌的四环螺萘醌衍生物。
Chartspiroton, a Tetracyclic Spiro-naphthoquinone Derivative from a Medicinal Plant Endophytic .
机构信息
Jiangsu Key Laboratory for Functional Substances of Chinese Medicine, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Key Laboratory of Elemene Class Anti-Cancer Chinese Medicine of Zhejiang Province, Engineering Laboratory of Development and Application of Traditional Chinese Medicine from Zhejiang Province, Holistic Integrative Pharmacy Institutes (HIPI), Hangzhou Normal University, Hangzhou 311121, China.
出版信息
Org Lett. 2020 May 15;22(10):3739-3743. doi: 10.1021/acs.orglett.0c00696. Epub 2020 Mar 18.
A novel 6/6/5/6 tetracyclic polyketide named chartspiroton () was isolated from a medicinal plant endophytic in The complete structure assignment with absolute stereochemistry was elucidated through spectroscopic data, computational calculations, and single-crystal X-ray diffraction. Chartspiroton features an unprecedented naphthoquinone derivative spiro-fused with a benzofuran lactone moiety. A plausible polyketide biosynthetic pathway for suggested intriguing oxidative rearrangement steps to form the five-membered lactone ring.
从药用植物内生真菌中分离得到一种新型 6/6/5/6 四环聚酮，命名为 chartspiroton ()。通过光谱数据、计算计算和单晶 X 射线衍射，阐明了其完整的结构，并确定了绝对立体化学。Chartspiroton 具有前所未有的萘醌衍生物与苯并呋喃内酯部分稠合的螺环结构。推测 的聚酮生物合成途径涉及有趣的氧化重排步骤，形成五元内酯环。
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