一株海洋来源真菌 SCSIO F452 中结构多样的多环水杨醛衍生物对映异构体。

CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China.

Southwest Center for Natural Products Research, University of Arizona, Tucson, AZ 85706, USA.

Mar Drugs. 2021 Sep 26;19(10):543. doi: 10.3390/md19100543.

To enlarge the chemical diversity of sp. SCSIO F452, a talented marine-derived fungus, we further investigated its chemical constituents from a large-scale fermentation with modified culture. Four pairs of new salicylaldehyde derivative enantiomers, euroticins F-I (-), as well as a known one eurotirumin () were isolated and characterized. Compound features an unprecedented constructed 6/6/6/5 tetracyclic structures, while and represent two new types of 6/6/5 scaffolds. Their structures were established by comprehensive spectroscopic analyses, X-ray diffraction, C NMR, and electronic circular dichroism calculations. Selected compounds showed significant inhibitory activity against α-glucosidase and moderate cytotoxic activities against SF-268, MCF-7, HepG2, and A549 cell lines.

为了扩大海洋来源真菌 SCSIO F452 的化学多样性，我们进一步对其进行了大规模发酵和改良培养，并对其化学成分进行了研究。从发酵产物中分离得到了 4 对新的水杨醛衍生物对映异构体（euroticin F-I (-)）和 1 个已知化合物（eurotirumin ()）。化合物具有前所未有的 6/6/6/5 四环结构，而和则代表两种新的 6/6/5 骨架类型。通过综合光谱分析、X 射线衍射、C NMR 和电子圆二色性计算确定了它们的结构。部分化合物对α-葡萄糖苷酶具有显著的抑制活性，对 SF-268、MCF-7、HepG2 和 A549 细胞系也具有中等的细胞毒性。