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猪蛔虫β-微管蛋白基因中无与苯并咪唑类药物耐药性相关的突变。

Absence of mutations associated with resistance to benzimidazole in the beta-tubulin gene of Ascaris suum.

机构信息

Microbiology Research Institute, Universidad Nacional Autónoma de Honduras (UNAH), Tegucigalpa, Honduras.

Department of Health Sciences, Brock University, St. Catharines, Ontario. Canada.

出版信息

Rev Soc Bras Med Trop. 2020 Mar 16;53:e20190155. doi: 10.1590/0037-8682-0155-2019. eCollection 2020.

DOI:10.1590/0037-8682-0155-2019
PMID:32187331
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7094045/
Abstract

INTRODUCTION

Benzimidazoles are commonly used for the control of veterinary nematodes. Resistance to benzimidazoles has been associated with three single nucleotide polymorphisms in the β-tubulin gene of common nematodes. However, these mutations are infrequent in the genus Ascaris spp.

METHODS

In order to determine mutations associated with benzimidazole resistance in Ascaris suum, worms were collected from slaughtered pigs and a partial region of the β-tubulin gene was sequenced.

RESULTS

All parasites showed the wildtype genotype for codons 167, 198, and 200 of the β-tubulin gene.

CONCLUSIONS

This is the first report of genetic sequences associated with benzimidazole resistance in A. suum.

摘要

简介

苯并咪唑类药物常用于兽医线虫的控制。β-微管蛋白基因中的三个单核苷酸多态性与常见线虫对苯并咪唑类药物的耐药性有关。然而，这些突变在蛔虫属中并不常见。

方法

为了确定与猪蛔虫对苯并咪唑类药物耐药性相关的突变，从屠宰猪中采集蠕虫，并对β-微管蛋白基因的部分区域进行测序。

结果

所有寄生虫的β-微管蛋白基因的 167、198 和 200 密码子均显示野生型基因型。

结论

这是首例与猪蛔虫对苯并咪唑类药物耐药性相关的遗传序列的报告。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71ef/7094045/3e51ad5f9e71/1678-9849-rsbmt-53-e20190155-gf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71ef/7094045/3e51ad5f9e71/1678-9849-rsbmt-53-e20190155-gf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/71ef/7094045/3e51ad5f9e71/1678-9849-rsbmt-53-e20190155-gf1.jpg

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