Cornelius Charles E
California Primate Research Center, University of California, Davis.
Am J Primatol. 1982;2(4):343-354. doi: 10.1002/ajp.1350020403.
Close similarities exist in the chemical structure of fetal and adult bile pigments and mechanisms for hepatic bilirubin conjugation and transport in human and nonhuman primates. Newborn monkeys, unlike other animals, develop physiologic hyperbilirubinemia and are ideal animal models in which to investigate this developmental human disorder. Aberrations in bile pigment metabolism and compartmentalization which occur in hemolytic, hepatocellular, and obstructive diseases, closely resemble those reported in counterpart syndromes in man. Similarities also exist in the mechanisms responsible for the secretion of canalicular and ductular/ductal bile and the composition of bile. Nonhuman primates offer distinct advantages for comparative studies concerning bile pigment metabolism and the secretion of bile.
胎儿和成人胆汁色素的化学结构，以及人类和非人类灵长类动物肝脏胆红素结合与转运机制存在密切相似性。与其他动物不同，新生猴子会出现生理性高胆红素血症，是研究这种人类发育性疾病的理想动物模型。溶血性、肝细胞性和阻塞性疾病中发生的胆汁色素代谢和分隔异常，与人类相应综合征中报道的情况极为相似。在胆小管和胆管/导管胆汁分泌机制以及胆汁成分方面也存在相似之处。非人类灵长类动物在胆汁色素代谢和胆汁分泌的比较研究中具有明显优势。
