Antiplasmodial Activity of (Sprague) Sprague Ethyl Acetate Extract in -Infected Mice.

BACKGROUND

One of the most dangerous Plasmodium species is . Hence, it causes a higher rate of mortality. The resistance of to the ACT (Artemisinin-based Combination Therapies) has led to the search for new antimalarial drugs. The purpose of this research was to assess the antiplasmodial activity of ethyl acetate extract to provide a scientific basis for the use of this medicinal plant to treat malaria.

METHODS

stem bark powder was macerated in ethyl acetate to obtain the extract. The extract liquid filtrate was concentrated, evaporated and dry using a Rotavapor. The Peter and Rane test were used for the suppressive and curative antiplasmodial activities at different doses (125, 250 and 500 mg/kg). A positive and negative control groups were administered chloroquine (5 mg/kg) and 10% hypromelose, respectively. To assess the parasitemia of the mice a thin blood smear was made.

RESULTS

The ethyl acetate extract completely (100%) inhibited the development of in the suppressive test at the dose of 500 mg/kg while that of the curative test was inhibited at 95%. The extract-treated group (500 mg/kg) and (Chloroquine (5 mg/kg) group all survived. The negative control group recorded a 100% mortality rate.

CONCLUSION

The present study provides scientific confirmation on the use of stem bark as an antiplasmodial remedy. However, the identification of the mode of action and the purification of the active compounds are necessary for further studies.