Cornelia de Lange、脆性 X 综合征和 Rubinstein-Taybi 综合征患者社会互动技能和行为的观察性研究。
An Observational Study of Social Interaction Skills and Behaviors in Cornelia de Lange, Fragile X and Rubinstein-Taybi Syndromes.
机构信息
Cerebra Centre for Neurodevelopmental Disorders, School of Psychology, University of Birmingham, 52 Pritchatts Road, Edgbaston, B15 2TT, UK.
University of Surrey, Elizabeth Fry Building, Guildford, Surrey, GU2 7XH, UK.
出版信息
J Autism Dev Disord. 2020 Nov;50(11):4001-4010. doi: 10.1007/s10803-020-04440-4.
We directly assessed the broader aspects of sociability (social enjoyment, social motivation, social interaction skills and social discomfort) in individuals with Cornelia de Lange (CdLS), fragile X (FXS) and Rubinstein-Taybi syndromes (RTS), and their association with autism characteristics and chronological age in these groups. Individuals with FXS (p < 0.01) and RTS (p < 0.01) showed poorer quality of eye contact compared to individuals with CdLS. Individuals with FXS showed less person and more object attention than individuals with CdLS (p < 0.01). Associations between sociability and autism characteristics and chronological age differed between groups, which may indicate divergence in the development and aetiology of different components of sociability across these groups. Findings indicate that individuals with CdLS, FXS and RTS show unique profiles of sociability.
我们直接评估了康尼氏综合征（CdLS）、脆性 X 综合征（FXS）和鲁宾斯坦-泰比综合征（RTS）患者的社交能力的更广泛方面（社交乐趣、社交动机、社交互动技巧和社交不适），并评估了这些方面与自闭症特征和他们在这些群体中的实际年龄的关联。与 CdLS 患者相比，FXS（p < 0.01）和 RTS（p < 0.01）患者的目光接触质量较差。与 CdLS 患者相比，FXS 患者对人的关注较少，对物体的关注较多（p < 0.01）。社交能力与自闭症特征和实际年龄之间的关联在不同组别之间存在差异，这可能表明不同组别社交能力不同组成部分的发展和病因存在差异。研究结果表明，CdLS、FXS 和 RTS 患者表现出独特的社交能力特征。
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