Costa-Paiva Elisa M, Coates Christopher J
Department of Zoology, Biociences Institute, University of Sao Paulo, Sao Paulo, Brazil.
Department of Biosciences, College of Science, Swansea University, Swansea, SA2 8PP, UK.
Subcell Biochem. 2020;94:251-273. doi: 10.1007/978-3-030-41769-7_10.
There are three broad groups of oxygen-transport proteins found in the haemolymph (blood) of invertebrates, namely the hemocyanins, the hemerythrins and the globins. Both hemerythrins and extracellular globins are iron-based proteins that are understudied when compared to the copper-containing hemocyanins. Recent evidence suggests that hemerythrins and (giant) extracellular globins (and their linker chains) are more widely distributed than previously thought and may have biological functions beyond oxygen transport and storage. Herein, we review contemporary literature of these often-neglected proteins with respect to their structural configurations on formation and ancestral states.
在无脊椎动物的血淋巴（血液）中发现了三大类氧运输蛋白，即血蓝蛋白、蚯蚓血红蛋白和球蛋白。与含铜的血蓝蛋白相比，蚯蚓血红蛋白和细胞外球蛋白这两种以铁为基础的蛋白质的研究较少。最近的证据表明，蚯蚓血红蛋白和（巨型）细胞外球蛋白（及其连接链）的分布比以前认为的更广泛，并且可能具有除氧运输和储存之外的生物学功能。在此，我们回顾了这些常被忽视的蛋白质在结构构型、形成和原始状态方面的当代文献。
