• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Role of eIF4E on epithelial-mesenchymal transition, invasion, and chemoresistance of prostate cancer cells.

作者信息

Liu Xujie, Vaidya Amita M, Sun Da, Zhang Yan, Ayat Nadia, Schilb Andrew, Lu Zheng-Rong

机构信息

Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, 44106, USA.

出版信息

Cancer Commun (Lond). 2020 Mar;40(2-3):126-131. doi: 10.1002/cac2.12011. Epub 2020 Mar 18.

DOI:10.1002/cac2.12011
PMID:32189455
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7144414/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0689/7144414/0ea1c2aa0b7e/CAC2-40-126-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0689/7144414/888494fd4016/CAC2-40-126-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0689/7144414/e902c924430d/CAC2-40-126-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0689/7144414/0ea1c2aa0b7e/CAC2-40-126-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0689/7144414/888494fd4016/CAC2-40-126-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0689/7144414/e902c924430d/CAC2-40-126-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0689/7144414/0ea1c2aa0b7e/CAC2-40-126-g003.jpg

相似文献

1
Role of eIF4E on epithelial-mesenchymal transition, invasion, and chemoresistance of prostate cancer cells.真核生物翻译起始因子4E（eIF4E）在前列腺癌细胞上皮-间质转化、侵袭及化疗耐药中的作用
Cancer Commun (Lond). 2020 Mar;40(2-3):126-131. doi: 10.1002/cac2.12011. Epub 2020 Mar 18.
2
Knockdown of eukaryotic translation initiation factor 4E suppresses cell growth and invasion, and induces apoptosis and cell cycle arrest in a human lung adenocarcinoma cell line.真核生物翻译起始因子4E的敲低抑制人肺腺癌细胞系的细胞生长和侵袭，并诱导细胞凋亡和细胞周期停滞。
Mol Med Rep. 2015 Dec;12(6):7971-8. doi: 10.3892/mmr.2015.4468. Epub 2015 Oct 21.
3
AEG-1 induces gastric cancer metastasis by upregulation of eIF4E expression.AEG-1 通过上调 eIF4E 表达促进胃癌转移。
J Cell Mol Med. 2017 Dec;21(12):3481-3493. doi: 10.1111/jcmm.13258. Epub 2017 Jun 29.
4
Crosstalk between epithelial-mesenchymal transition and castration resistance mediated by Twist1/AR signaling in prostate cancer.Twist1/AR信号通路介导的上皮-间质转化与前列腺癌去势抵抗之间的串扰
Endocr Relat Cancer. 2015 Dec;22(6):889-900. doi: 10.1530/ERC-15-0225. Epub 2015 Aug 26.
5
The role of epithelial-mesenchymal transition drivers ZEB1 and ZEB2 in mediating docetaxel-resistant prostate cancer.上皮-间质转化驱动因子ZEB1和ZEB2在介导多西他赛耐药前列腺癌中的作用。
Mol Oncol. 2017 Mar;11(3):251-265. doi: 10.1002/1878-0261.12030. Epub 2017 Jan 30.
6
The role of eIF4E in response and acquired resistance to vemurafenib in melanoma.真核生物翻译起始因子4E（eIF4E）在黑色素瘤对维莫非尼的反应及获得性耐药中的作用
J Invest Dermatol. 2015 May;135(5):1368-1376. doi: 10.1038/jid.2015.11. Epub 2015 Jan 23.
7
Knockdown of eIF4E suppresses cell proliferation, invasion and enhances cisplatin cytotoxicity in human ovarian cancer cells.抑制真核生物翻译起始因子4E（eIF4E）可抑制人卵巢癌细胞的增殖、侵袭，并增强顺铂的细胞毒性。
Int J Oncol. 2015 Dec;47(6):2217-25. doi: 10.3892/ijo.2015.3201. Epub 2015 Oct 13.
8
Eukaryotic Translation Initiation Factor 4E Is a Feed-Forward Translational Coactivator of Transforming Growth Factor β Early Protransforming Events in Breast Epithelial Cells.真核生物翻译起始因子4E是乳腺上皮细胞中转化生长因子β早期前转化事件的前馈翻译共激活因子。
Mol Cell Biol. 2015 Aug;35(15):2597-609. doi: 10.1128/MCB.00324-15. Epub 2015 May 18.
9
CX3CL1 increases invasiveness and metastasis by promoting epithelial-to-mesenchymal transition through the TACE/TGF-α/EGFR pathway in hypoxic androgen-independent prostate cancer cells.在缺氧的雄激素非依赖性前列腺癌细胞中，CX3CL1通过TACE/TGF-α/EGFR途径促进上皮-间质转化，从而增加侵袭性和转移能力。
Oncol Rep. 2016 Feb;35(2):1153-62. doi: 10.3892/or.2015.4470. Epub 2015 Dec 2.
10
Cell death under epithelial-mesenchymal transition control in prostate cancer therapeutic response.前列腺癌治疗反应中上皮-间质转化控制下的细胞死亡
Int J Urol. 2018 Apr;25(4):318-326. doi: 10.1111/iju.13505. Epub 2018 Jan 17.

引用本文的文献

1
The role of m5C, m1A and m7G modifications in tumors of urinary system.m5C、m1A和m7G修饰在泌尿系统肿瘤中的作用。
Front Cell Dev Biol. 2025 Jul 30;13:1549588. doi: 10.3389/fcell.2025.1549588. eCollection 2025.
2
MR Molecular Imaging of Extradomain-B Fibronectin for Assessing Progression and Therapy Resistance of Prostate Cancer.用于评估前列腺癌进展和治疗抗性的胞外区域B纤连蛋白的磁共振分子成像
Chem Biomed Imaging. 2024 Jun 11;2(8):560-568. doi: 10.1021/cbmi.4c00002. eCollection 2024 Aug 26.
3
Analysis of mG methylation modification patterns and pulmonary vascular immune microenvironment in pulmonary arterial hypertension.

本文引用的文献

1
Systemic Delivery of Tumor-Targeting siRNA Nanoparticles against an Oncogenic LncRNA Facilitates Effective Triple-Negative Breast Cancer Therapy.系统递送靶向肿瘤的 siRNA 纳米颗粒对抗致癌长链非编码 RNA 有助于有效治疗三阴性乳腺癌。
Bioconjug Chem. 2019 Mar 20;30(3):907-919. doi: 10.1021/acs.bioconjchem.9b00028. Epub 2019 Feb 21.
2
Cancer statistics, 2019.癌症统计数据，2019 年。
CA Cancer J Clin. 2019 Jan;69(1):7-34. doi: 10.3322/caac.21551. Epub 2019 Jan 8.
3
eIF4E Phosphorylation in Prostate Cancer.前列腺癌中的 eIF4E 磷酸化。
分析肺动脉高压中 mG 甲基化修饰模式与肺血管免疫微环境。
Front Immunol. 2022 Dec 5;13:1014509. doi: 10.3389/fimmu.2022.1014509. eCollection 2022.
4
NXN suppresses metastasis of hepatocellular carcinoma by promoting degradation of Snail through binding to DUB3.NXN 通过与 DUB3 结合促进 Snail 的降解来抑制肝癌的转移。
Cell Death Dis. 2022 Aug 4;13(8):676. doi: 10.1038/s41419-022-05135-7.
Neoplasia. 2018 Jun;20(6):563-573. doi: 10.1016/j.neo.2018.04.003. Epub 2018 May 4.
4
Tumour heterogeneity and resistance to cancer therapies.肿瘤异质性与癌症治疗耐药性。
Nat Rev Clin Oncol. 2018 Feb;15(2):81-94. doi: 10.1038/nrclinonc.2017.166. Epub 2017 Nov 8.
5
Targeted Multifunctional Lipid ECO Plasmid DNA Nanoparticles as Efficient Non-viral Gene Therapy for Leber's Congenital Amaurosis.靶向多功能脂质ECO质粒DNA纳米颗粒作为莱伯先天性黑蒙的高效非病毒基因治疗手段
Mol Ther Nucleic Acids. 2017 Jun 16;7:42-52. doi: 10.1016/j.omtn.2017.02.005. Epub 2017 Feb 28.
6
Targeted Dual pH-Sensitive Lipid ECO/siRNA Self-Assembly Nanoparticles Facilitate In Vivo Cytosolic sieIF4E Delivery and Overcome Paclitaxel Resistance in Breast Cancer Therapy.靶向双pH敏感脂质ECO/siRNA自组装纳米颗粒促进体内细胞溶质sieIF4E递送并克服乳腺癌治疗中的紫杉醇耐药性。
Adv Healthc Mater. 2016 Nov;5(22):2882-2895. doi: 10.1002/adhm.201600677. Epub 2016 Oct 10.
7
Self-Assembly of a Multifunctional Lipid With Core-Shell Dendrimer DNA Nanoparticles Enhanced Efficient Gene Delivery at Low Charge Ratios into RPE Cells.一种具有核壳树枝状聚合物DNA纳米颗粒的多功能脂质的自组装增强了在低电荷比下向视网膜色素上皮细胞的高效基因递送。
Macromol Biosci. 2015 Dec;15(12):1663-72. doi: 10.1002/mabi.201500192. Epub 2015 Aug 13.
8
Spatial genomic heterogeneity within localized, multifocal prostate cancer.局限性、多灶性前列腺癌的空间基因组异质性。
Nat Genet. 2015 Jul;47(7):736-45. doi: 10.1038/ng.3315. Epub 2015 May 25.
9
EMT and tumor metastasis.上皮-间质转化与肿瘤转移
Clin Transl Med. 2015 Feb 26;4:6. doi: 10.1186/s40169-015-0048-3. eCollection 2015.
10
Deciphering the cellular source of tumor relapse identifies CD44 as a major therapeutic target in pancreatic adenocarcinoma.破解肿瘤复发的细胞来源可确定CD44是胰腺腺癌的主要治疗靶点。
Oncotarget. 2015 Apr 10;6(10):7408-23. doi: 10.18632/oncotarget.3510.