Senior Resident, Department of Pathology, Lady Hardinge Medical College, New Delhi, India.
Assistant Professor, Department of Pathology, Lady Hardinge Medical College, New Delhi, India.
Indian J Public Health. 2020 Jan-Mar;64(1):93-95. doi: 10.4103/ijph.IJPH_223_19.
We report the case of a 22-year-old primigravida detected as having sickle cell disease (SCD), initially presenting in the third trimester (30 week) of pregnancy. The patient came to our center with a complaint of severe lower limb pain. The peripheral smear showed marked anisopoikilocytosis, numerous leptocytes, sickle cells, and target cells. High-performance liquid chromatography corroborated the diagnosis of SCD, showing a significant peak in the sickle window. The patient was conservatively managed and delivered a healthy baby through normal vaginal delivery. Delayed presentation of SCD in the third trimester of pregnancy is unusual. This report aims to bring attention to the possible causes of such a lag in detection. We also suggest measures to refine the antenatal healthcare screening at multiple levels, with regard to the detection of sickle cell hemoglobinopathy.
我们报告了一例 22 岁初产妇的病例，该产妇在妊娠第 30 周时被诊断为镰状细胞病（SCD）。该患者因下肢严重疼痛来到我们中心。外周血涂片显示明显的异形红细胞增多症、大量泪滴细胞、镰状细胞和靶细胞。高效液相色谱法证实了 SCD 的诊断，在镰状细胞窗口显示出明显的高峰。该患者接受了保守治疗，并通过正常阴道分娩产下了一名健康的婴儿。妊娠晚期 SCD 的迟发表现并不常见。本报告旨在引起对这种延迟检测的可能原因的关注。我们还建议采取措施，在多个层面上完善产前保健筛查，以检测镰状细胞血红蛋白病。
