Zhang Jin-Jie, Shi Xiao-Rong, Lv Wen-Wen, Zhou Xiao-Long, Sun Ying-Dong, Li Bao-Yuan, Hu Xiao-Long
Department of Pharmacy, Binzhou Medical University Hospital, Binzhou 256603, China.
State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
Evid Based Complement Alternat Med. 2020 Feb 28;2020:2938432. doi: 10.1155/2020/2938432. eCollection 2020.
Oxidative stress (OS) is a crucial factor influencing the development of Parkinson's disease (PD). Here we first reported that Lindleyin (), one of the major components of rhubarb, possessed neuroprotective effects against HO-induced SH-SY5Y cell injury and MPTP-induced PD of C57BL/6 mice. The results showed that can decrease cell death and apoptotic rate induced by HO through inhibiting mitochondrial apoptotic pathway and increasing the activities of SOD, GSH-Px, and CAT as well as decreasing the level of MDA. In addition, in vivo studies showed that oral administration of (5 or 20 mg/kg) showed significant change in motor function deficits, antioxidant enzyme activities, apoptotic pathway, and tyrosine hydroxylase expression. Our results reveal that might be a promising anti-PD agent by reducing OS and apoptosis.
氧化应激（OS）是影响帕金森病（PD）发展的关键因素。在此，我们首次报道，大黄的主要成分之一芦荟大黄素对过氧化氢（HO）诱导的SH-SY5Y细胞损伤和1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）诱导的C57BL/6小鼠PD具有神经保护作用。结果表明，芦荟大黄素可通过抑制线粒体凋亡途径、提高超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）和过氧化氢酶（CAT）的活性以及降低丙二醛（MDA）水平，减少HO诱导的细胞死亡和凋亡率。此外，体内研究表明，口服芦荟大黄素（5或20mg/kg）可使运动功能缺陷、抗氧化酶活性、凋亡途径和酪氨酸羟化酶表达发生显著变化。我们的结果表明，芦荟大黄素可能通过减轻氧化应激和细胞凋亡成为一种有前景的抗PD药物。
