Khalil Rafaat H, Al-Humadi Nabil
Department of Biology, College of Science and Technology, Florida Agricultural and Mechanical University, Tallahassee, FL 32307, USA.
Office of Vaccines, Food and Drug Administration, Center for Biologics Evaluation and Research, Silver Spring, MD 20993, USA.
Biomed Rep. 2020 Apr;12(4):143-152. doi: 10.3892/br.2020.1276. Epub 2020 Feb 11.
Vaccines are considered to be one of the most cost-effective life-saving interventions in human history. The body's inflammatory response to vaccines has both desired effects (immune response), undesired effects [(acute phase reactions (APRs)] and trade-offs. Trade-offs are more potent immune responses which may be potentially difficult to separate from potent acute phase reactions. Thus, studying acute phase proteins (APPs) during vaccination may aid our understanding of APRs and homeostatic changes which can result from inflammatory responses. Depending on the severity of the response in humans, these reactions can be classified as major, moderate or minor. In this review, types of APPs and their importance in vaccination will be discussed.
疫苗被认为是人类历史上最具成本效益的挽救生命的干预措施之一。人体对疫苗的炎症反应既有预期效果(免疫反应)、非预期效果[(急性期反应(APRs)],也存在权衡。权衡是指更强的免疫反应,可能难以与强烈的急性期反应区分开来。因此,研究疫苗接种期间的急性期蛋白(APPs)可能有助于我们理解急性期反应以及炎症反应可能导致的体内稳态变化。根据人类反应的严重程度,这些反应可分为重度、中度或轻度。在本综述中,将讨论APPs的类型及其在疫苗接种中的重要性。