Hashimoto Kazuhiko, Nishimura Shunji, Oka Naohiro, Akagi Masao
Department of Orthopaedic Surgery, Kindai University Hospital, Osaka-Sayama, Osaka 589-8511, Japan.
Mol Clin Oncol. 2020 Apr;12(4):358-364. doi: 10.3892/mco.2020.1994. Epub 2020 Feb 4.
The aim of the present study was to investigate the clinical outcomes of adolescents and young adults with bone and soft tissue sarcomas. Records of seven male and six female patients aged 17-39 years with bone or soft tissue sarcomas were reviewed retrospectively; data on histology, size, location, grade/stage, treatment, recurrence, presence of metastasis, and prognosis were retrieved. Five-year survival rates were estimated using the Kaplan-Meier method and were compared according to age, sarcoma type, histological grade, and location. Seven and six patients had bone and soft tissue sarcomas, respectively. In terms of histology, patients with bone sarcomas included four with osteosarcoma, two with chondrosarcoma, and one with Ewing sarcoma of the bone. Of those with soft tissue sarcomas, three had liposarcomas, two had synovial sarcomas, and one each had Ewing sarcoma and leiomyosarcoma. The five-year survival rate of the cohort was 57.1%. Younger patients with sarcoma had poorer survival than older patients. Patients with high-grade sarcomas also had poorer survival than those with low-grade tumors. In addition, patients with trunk-located tumors had poorer survival than those with tumors in the extremities. These findings suggest that, younger adolescents and young adults with high-grade or trunk-located sarcomas require more aggressive treatment.
本研究的目的是调查青少年和青年骨肉瘤及软组织肉瘤患者的临床结局。回顾性分析了7例男性和6例女性年龄在17 - 39岁的骨肉瘤或软组织肉瘤患者的记录；收集了组织学、大小、位置、分级/分期、治疗、复发、转移情况及预后等数据。采用Kaplan-Meier方法估计5年生存率，并根据年龄、肉瘤类型、组织学分级和位置进行比较。分别有7例和6例患者患有骨肉瘤和软组织肉瘤。在组织学方面，骨肉瘤患者中4例为骨肉瘤，2例为软骨肉瘤，1例为骨尤文肉瘤。软组织肉瘤患者中，3例为脂肪肉瘤，2例为滑膜肉瘤，1例为尤文肉瘤，1例为平滑肌肉瘤。该队列的5年生存率为57.1%。肉瘤年轻患者的生存率低于年长患者。高级别肉瘤患者的生存率也低于低级别肿瘤患者。此外，躯干部位肿瘤患者的生存率低于四肢肿瘤患者。这些发现表明，患有高级别或躯干部位肉瘤的青少年和青年需要更积极的治疗。
