接受二甲双胍治疗的糖尿病患者的维生素B12缺乏症：来自阿曼的一项横断面研究。
Vitamin B12 Deficiency in Diabetic Patients on Metformin Therapy: A cross-sectional study from Oman.
作者信息
Al-Hamdi Ahmed, Al-Gahhafi Mohammed, Al-Roshdi Shihab, Jaju Sanjay, Al-Mamari Ali, Al Mahrezi Abdulaziz M
机构信息
Directorate of Health Services of North Batinah, Ministry of Health, Sohar, Oman.
Directorate General of Health Services of North Sharqiya, Ministry of Health, Mudhaibi, Oman.
出版信息
Sultan Qaboos Univ Med J. 2020 Feb;20(1):e90-e94. doi: 10.18295/squmj.2020.20.01.013. Epub 2020 Mar 9.
OBJECTIVES
This study aimed to determine the prevalence of vitamin B12 deficiency amongst diabetic patients on metformin therapy.
METHODS
This cross-sectional study was conducted at general clinics at the University Health Center and diabetes outpatient clinics at Sultan Qaboos University Hospital, Muscat, Oman, between January and December 2017. All Omani adults who were diagnosed with type 2 diabetes mellitus and took metformin were invited to participate in the study. The variables included in this study were age, gender, duration of diabetes, dose and duration of metformin therapy, haemoglobin and glycosylated haemoglobin level.
RESULTS
A total of 248 subjects were included (response rate = 95.4%) of which 26 (10.5%) were vitamin B12 deficient and 53 (21.4%) were borderline deficient. The mean daily dose of metformin was highest among vitamin B12 deficient group (1,981 ± 222 mg; = 0.004).
CONCLUSION
The prevalence of vitamin B12 deficiency is considerable among diabetic patients on metformin therapy. Further research is needed to confirm the need for routine screening and monitoring.
目的
本研究旨在确定接受二甲双胍治疗的糖尿病患者中维生素B12缺乏的患病率。
方法
本横断面研究于2017年1月至12月在阿曼马斯喀特苏丹卡布斯大学医院的大学健康中心综合诊所和糖尿病门诊进行。所有被诊断为2型糖尿病并服用二甲双胍的阿曼成年人受邀参与本研究。本研究纳入的变量包括年龄、性别、糖尿病病程、二甲双胍治疗剂量和疗程、血红蛋白及糖化血红蛋白水平。
结果
共纳入248名受试者（应答率=95.4%），其中26名（10.5%）维生素B12缺乏，53名（21.4%）临界缺乏。维生素B12缺乏组的二甲双胍日均剂量最高（1,981±222毫克；P=0.004）。
结论
接受二甲双胍治疗的糖尿病患者中维生素B12缺乏的患病率相当高。需要进一步研究以证实是否有必要进行常规筛查和监测。
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