Jayarajah Umesh, Nagodavithane Kavinda, Basnayake Oshan, Seneviratne Sanjeewa
Professorial Surgical Unit, National Hospital of Sri Lanka, Colombo, Sri Lanka.
Department of Surgery, Faculty of Medicine, University of Colombo, Sri Lanka.
Case Rep Oncol Med. 2020 Mar 1;2020:5768438. doi: 10.1155/2020/5768438. eCollection 2020.
Radiation-induced sarcoma of the breast is an iatrogenic malignancy that occurs secondary to radiotherapy, which is most commonly given following breast conservation surgery. It has an incidence of 3.2 per 1,000 patients at 15 years and is associated with a poor prognosis. We report a 62-year-old female with a history of bilateral breast conservation surgery and radiotherapy 5 years ago presenting with bilateral angiosarcoma. This case report highlights the importance of considering radiation-induced angiosarcoma of the breast as a differential diagnosis in a patient with recurrent breast neoplasms. The challenges in the management with recent evidence on new treatment modalities are discussed.
乳腺放射性肉瘤是一种因放疗引发的医源性恶性肿瘤，最常见于保乳手术后进行放疗的患者。其15年发病率为每1000例患者中有3.2例，预后较差。我们报告一名62岁女性，有双侧保乳手术及放疗史，5年前接受放疗，现出现双侧血管肉瘤。本病例报告强调了对于复发性乳腺肿瘤患者，将乳腺放射性血管肉瘤作为鉴别诊断的重要性。同时讨论了近期新治疗模式证据下管理方面的挑战。
