关于喹啉衍生物作为抗耐甲氧西林金黄色葡萄球菌（MRSA）药物的综述。
A review on quinoline derivatives as anti-methicillin resistant (MRSA) agents.
作者信息
Kumar Pradeep
机构信息
Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab, Bathinda, 151001 India.
出版信息
BMC Chem. 2020 Mar 13;14(1):17. doi: 10.1186/s13065-020-00669-3. eCollection 2020 Dec.
Abstract
Methicillin Resistant (MRSA) consists of strains of which are resistant to methicillin. The resistance is due to the acquisition of mecA gene which encodes PBP2a unlike of any PBPs normally produced by . PBP2a shows unusually low β-Lactam affinity and remains active to allow cell wall synthesis at normally lethal β-Lactam concentrations. MRSA can cause different types of infections like Healthcare associated MRSA, Community associated MRSA and Livestock associated MRSA infections. It causes skin lesions, osteomyelitis, endocarditis and furunculosis. To treat MRSA infections, only a few options are available like vancomycin, clindamycin, co-trimoxazole, fluoroquinolones or minocycline and there is a dire need of discovering new antibacterial agents that can effectively treat MRSA infections. In the current review, an attempt has been made to compile the data of quinoline derivatives possessing anti-MRSA potential reported to date.
摘要
耐甲氧西林金黄色葡萄球菌（MRSA）由对甲氧西林耐药的菌株组成。这种耐药性是由于获得了mecA基因，该基因编码的PBP2a与该菌通常产生的任何PBPs不同。PBP2a显示出异常低的β-内酰胺亲和力，并在通常致死的β-内酰胺浓度下仍保持活性以允许细胞壁合成。MRSA可引起不同类型的感染，如医疗保健相关的MRSA感染、社区相关的MRSA感染和家畜相关的MRSA感染。它会导致皮肤病变、骨髓炎、心内膜炎和疖病。治疗MRSA感染只有少数几种选择，如万古霉素、克林霉素、复方新诺明、氟喹诺酮类或米诺环素，迫切需要发现能够有效治疗MRSA感染的新型抗菌剂。在当前的综述中，已尝试汇编迄今报道的具有抗MRSA潜力的喹啉衍生物的数据。
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