Department of Health Sciences, University "Magna Græcia" of Catanzaro, 88100 Catanzaro, Italy.
Neuroimaging Unit, Institute of Bioimaging and Molecular Physiology, National Research Council (IBFM-CNR) Viale Europa, 88100 Catanzaro, Italy.
Int J Mol Sci. 2020 Mar 17;21(6):2041. doi: 10.3390/ijms21062041.
Malignant transformation is a multistep process in which several molecular entities become dysregulated and result in dysfunction in the regulation of cell proliferation. In past years, scientists have gradually dissected the pathways involved in the regulation of the cell cycle. The mitotic ubiquitin-conjugating enzymes UbcH10, has been extensively studied since its cloning and characterization and it has been identified as a constantly overexpressed factor in many types of cancer. In this paper, we have reviewed the literature about UbcH10 in human cancer, pointing out the association between its overexpression and exacerbation of cancer phenotype. Moreover, many recalled studied demonstrated how immunohistochemistry or RT-PCR analysis can distinguish normal tissues and benign lesions from malignant neoplasms. In other experimental studies, many of the consequences of UbcH10 overexpression, such as increased proliferation, metastasizing, cancer progression and resistance to anticancer drugs are reversed through gene silencing techniques. In recent years, many authors have defined UbcH10 evaluation in cancer patients as a useful tool for diagnosis and therapy. This opinion is shared by the authors who advertise how it would be useful to start using in clinical practice the notions acquired about this important moleculein the carcinogenesis of many human malignancies.
恶性转化是一个多步骤的过程，在此过程中，一些分子实体变得失调，导致细胞增殖的调节功能失常。在过去的几年中，科学家们逐渐剖析了参与细胞周期调控的途径。自从 UbcH10 被克隆和鉴定以来，它作为一种在许多类型的癌症中经常过度表达的因子，已经得到了广泛的研究。在本文中，我们回顾了关于 UbcH10 在人类癌症中的文献，指出了其过度表达与癌症表型恶化之间的关联。此外，许多回顾性研究表明，免疫组织化学或 RT-PCR 分析如何能够区分正常组织和良性病变与恶性肿瘤。在其他实验研究中，通过基因沉默技术，UbcH10 过度表达的许多后果，如增加增殖、转移、癌症进展和对抗癌药物的耐药性，都得到了逆转。近年来，许多作者将 UbcH10 在癌症患者中的评估定义为诊断和治疗的有用工具。作者们也认同这一观点，认为在临床实践中开始使用关于这种在许多人类恶性肿瘤发生过程中重要分子的认识是有用的。
