Department of Gynaecology and Obstetrics, Bengbu City, China.
Department of Pathology, the First Affiliated Hospital of Bengbu Medical University, Bengbu City, China.
Medicine (Baltimore). 2023 May 19;102(20):e33834. doi: 10.1097/MD.0000000000033834.
Ubiquitin-conjugating enzyme E2C (UBE2C), its overexpression promotes tumor progression, is a key component of the ubiquitin conjugating proteasome complex. Epithelial-mesenchymal transition, which is lost epithelial features and gained mesenchymal features in some epithelial cancers, is involved in epithelial cancers' invasiveness and metastasis. The aim of this study is to detect the expression of UBE2C, WNT5α, and E-cad in endometrial cancer (EC) and their clinical significance. The expression of UBE2C, WNT5α, and ZEB1 in 125 cases EC tissues were detected by immunohistochemistry. Patients clinicopathological, demography, and follow-up data were also collected. Positive rates of expression of UBE2C and ZEB1 were significantly higher in EC tissues when compared with the control tissues. The positive expression of UBE2C and ZEB1 were positively associated with tumor stages, local lymph node metastasis, and International Federation of Gynecology and Obstetrics (FIGO) stages. The positive rate of expression of WNT5a was significantly lower in EC tissues when compared with the control tissues. And positive expression of E-cad was inversely related to tumor stages, lymph node metastasis stages, and FIGO stages. Kaplan-Meier analyses demonstrated that positive expression of UBE2C or ZEB1 for EC patients had unfavorably overall survival time when compared with patients with negative expression of UBE2C or ZEB1. And EC patients with positive expression of WNT5a had favorably overall survival time when compared with EC patients with negative expression of WNT5a. Multivariate analysis demonstrated that positive expression UBE2C, WNT5α, and ZEB1, as well as FIGO stages were independent prognostic factors for EC patients. UBE2C, ZEB1, and WNT5a should be considered promising biomarkers for EC patients' prognosis.
泛素结合酶 E2C (UBE2C)，其过表达促进肿瘤进展，是泛素连接蛋白酶体复合物的关键组成部分。上皮-间充质转化，某些上皮癌中上皮特征丧失和间充质特征获得，涉及上皮癌的侵袭和转移。本研究旨在检测UBE2C、WNT5α和 E-cad 在子宫内膜癌 (EC) 中的表达及其临床意义。采用免疫组织化学法检测 125 例 EC 组织中 UBE2C、WNT5α 和 ZEB1 的表达，并收集患者的临床病理、人口统计学和随访资料。结果显示，与对照组相比，UBE2C 和 ZEB1 在 EC 组织中的阳性表达率明显更高。UBE2C 和 ZEB1 的阳性表达与肿瘤分期、局部淋巴结转移和国际妇产科联合会 (FIGO) 分期呈正相关。与对照组相比，WNT5a 在 EC 组织中的阳性表达率明显降低。E-cad 的阳性表达与肿瘤分期、淋巴结转移分期和 FIGO 分期呈负相关。Kaplan-Meier 分析表明，与 UBE2C 或 ZEB1 阴性表达的 EC 患者相比，UBE2C 或 ZEB1 阳性表达的 EC 患者总生存时间较差。与 WNT5a 阴性表达的 EC 患者相比，WNT5a 阳性表达的 EC 患者总生存时间较好。多因素分析表明，UBE2C、WNT5α 和 ZEB1 的阳性表达以及 FIGO 分期是 EC 患者的独立预后因素。UBE2C、ZEB1 和 WNT5a 可作为 EC 患者预后的有前途的生物标志物。
