Department of Precision Medicine, Università Degli Studi Della Campania L. Vanvitelli, Naples, Italy.
Department of Precision Medicine, Università Degli Studi Della Campania L. Vanvitelli, Naples, Italy.
Best Pract Res Clin Rheumatol. 2019 Dec;33(6):101493. doi: 10.1016/j.berh.2020.101493. Epub 2020 Mar 16.
Spondyloarthritis (SpA) is a group of chronic, inflammatory rheumatic diseases mainly affecting the axial skeleton. Although the pathogenesis of the disease remains elusive, alterations of intestinal microbial composition have been demonstrated in patients with SpA and associated with intestinal and systemic immune alterations. Substantial data have been published in recent years in ethnically different patient populations, demonstrating in a consolidated way the presence of alterations in the composition of the microbial flora in patients with SpA. It is not currently possible to establish whether these alterations are intrinsically inherent in the disease, for example, the effect of particular genes that confer susceptibility to the disease itself, or are a consequence of a more systemic inflammatory process that also involves the intestine. However, data deriving from animal models and studies on relatives of patients with SpA strongly suggest that these alterations might precede the onset of the disease. In this review, we will try to critically analyze studies on dysbiosis in SpA and animal models of SpA, analyzing their functional consequences and the impact of biotechnological therapies on intestinal bacterial composition.
脊柱关节炎（SpA）是一组主要影响中轴骨骼的慢性炎症性风湿病。尽管疾病的发病机制仍不清楚，但已在 SpA 患者中证实了肠道微生物组成的改变，并与肠道和全身免疫改变有关。近年来，在不同种族的患者群体中发表了大量数据，以综合的方式证明了 SpA 患者的微生物菌群组成存在改变。目前尚不能确定这些改变是否是疾病本身所固有的，例如，赋予疾病易感性的特定基因的影响，或者是更系统性炎症过程的结果，该过程也涉及肠道。然而，来自动物模型和 SpA 患者亲属的研究数据强烈表明，这些改变可能先于疾病的发生。在这篇综述中，我们将尝试批判性地分析 SpA 中的肠道菌群失调和 SpA 动物模型的研究，分析它们的功能后果以及生物技术治疗对肠道细菌组成的影响。
