Faculty of Medicine, Department of Physical Medicine and Rehabilitation, Cukurova University, Adana, Turkey.
Clin Rheumatol. 2024 Mar;43(3):851-861. doi: 10.1007/s10067-023-06708-3. Epub 2023 Jul 20.
Polymyalgia rheumatica is one of the most common inflammatory rheumatic conditions in older adults. The disease is characterized by pain and stiffness in the shoulder and pelvic girdle. Polymyalgia rheumatica is almost always observed in adults over the age of 50. The current article aimed to provide explanations for the age preference of polymyalgia rheumatica by reviewing the literature regarding disease etiology and pathogenesis. Potential factors related to the association between polymyalgia rheumatica and aging include immunosenescence/inflammaging, increased risk of infections by aging, endocrinosenescence, and age-related changes in gut microbiota. These factors and their potential contributions to immune-mediated inflammation will be discussed.
巨细胞动脉炎是老年人中最常见的炎症性风湿疾病之一。该病的特征是肩部和骨盆带疼痛和僵硬。巨细胞动脉炎几乎只发生在 50 岁以上的成年人中。本文旨在通过复习有关疾病病因和发病机制的文献，解释巨细胞动脉炎的发病年龄偏好。与巨细胞动脉炎和衰老相关的潜在因素包括免疫衰老/炎症衰老、衰老时感染风险增加、内分泌衰老以及与年龄相关的肠道微生物组变化。本文将讨论这些因素及其对免疫介导炎症的潜在贡献。
