Fondazione Policlinico Universitario A. Gemelli IRCCS - UOC Neurologia - Dipartmento Scienze dell'Invecchiamento, Neurologiche, Ortopediche e della Testa-Collo, Rome, Italy.
Department of Psychology, Area of Neuroscience, University of Rome 'Sapienza', Rome, Italy.
Clin Neurophysiol. 2020 May;131(5):1011-1018. doi: 10.1016/j.clinph.2020.02.015. Epub 2020 Mar 5.
Recent findings suggested that subclinical epileptiform activity is prevalent during sleep in a significant proportion of Alzheimer's Disease (AD) patients.
(A) comparing the frequency of subclinical epileptiform activity during the sleep in a sample diagnosed with 'probable' AD and Mild Cognitive Impairment (MCI) due to AD, and in healthy subjects; (B) evaluating epileptiform EEG activity as a function of different sleep stages within a well-controlled polysomnographic setting.
We prospectively enrolled 50 'probable' AD patients (73 ± 7.0 years) and 50 subjects with MCI due to AD (72 ± 6.7 years) without history of seizures, comparing them with 50 controls (69 ± 6.7 years). Patients underwent to a full-night video-PSG.
Subclinical epileptiform activity was detected in 6.38% of 'probable' AD patients, 11.63% of MCI due to AD subjects and 4.54% of controls (p = 0.43). The comparisons between the three groups for the frequency of epileptiform activity did not reach statistically significant differences neither for total sleep nor for any sleep period considered.
Our study shows that, when controlling for sleep stages and the influence of psychoactive drugs, AD patients and MCI due to AD subjects do not exhibit a higher frequency of epileptiform discharges during sleep compared to healthy subjects.
Subclinical epileptiform activity during sleep does not discriminate 'probable' AD from MCI due to AD and healthy controls.
最近的研究结果表明，在相当一部分阿尔茨海默病（AD）患者中，亚临床癫痫样活动在睡眠期间普遍存在。
（A）比较在诊断为“可能”AD 和 AD 引起的轻度认知障碍（MCI）的样本中以及在健康受试者中睡眠期间亚临床癫痫样活动的频率；（B）在经过良好控制的多导睡眠图设置中，评估癫痫样 EEG 活动作为不同睡眠阶段的函数。
我们前瞻性地招募了 50 名“可能”AD 患者（73 ± 7.0 岁）和 50 名 AD 引起的 MCI 患者（72 ± 6.7 岁），这些患者没有癫痫发作史，并将他们与 50 名健康对照组（69 ± 6.7 岁）进行比较。患者接受了整夜视频 PSG 检查。
6.38%的“可能”AD 患者、11.63%的 AD 引起的 MCI 患者和 4.54%的对照组检测到亚临床癫痫样活动（p = 0.43）。在总睡眠时间和任何考虑的睡眠期间，三组之间的癫痫样活动频率比较均未达到统计学显著差异。
我们的研究表明，在控制睡眠阶段和精神活性药物的影响时，AD 患者和 AD 引起的 MCI 患者在睡眠期间的癫痫样放电频率并不高于健康受试者。
睡眠期间的亚临床癫痫样活动不能区分“可能”AD 与 AD 引起的 MCI 和健康对照。
