Department of Anatomy and Cell Biology, MS 5035, Indiana University School of Medicine, 635 Barnhill Dr, Indianapolis, IN, 46202, USA.
Department of Medicine - Division of Nephrology, Indiana University School of Medicine, Indianapolis, IN, USA.
Curr Osteoporos Rep. 2020 Jun;18(3):242-246. doi: 10.1007/s11914-020-00580-9.
Kidney disease imparts profound skeletal changes, and unlike many other skeletal diseases, cortical bone is predominantly impacted. Significant advances in medical imaging have led to our ability to now obtain high-resolution three-dimensional views of cortical bone. This paper overviews recent work focused on cortical bone imaging, specifically cortical porosity, in kidney disease.
Although a number of clinical papers have used high-resolution imaging to assess cortical bone porosity, the most impactful work involves longitudinal study designs that have assessed cortical porosity changes over time. These latter studies demonstrate dramatic increases in cortical porosity in untreated individuals and a lack of clear efficacy in reversing porosity with treatment (although data are limited). Those papers providing longitudinal assessment, both clinical and pre-clinical, reveal powerful data about cortical porosity and provide a foundation upon which future studies can build.
肾脏疾病会引起严重的骨骼变化，与许多其他骨骼疾病不同，皮质骨是主要受影响的部位。医学影像学的显著进步使我们现在能够获得皮质骨的高分辨率三维视图。本文综述了最近关于肾脏疾病皮质骨成像（特别是皮质骨孔隙率）的研究进展。
尽管许多临床研究已经使用高分辨率成像来评估皮质骨孔隙率，但最具影响力的工作涉及纵向研究设计，这些设计评估了随时间变化的皮质骨孔隙率变化。这些后续研究表明，未经治疗的个体的皮质骨孔隙率显著增加，并且治疗对孔隙率的逆转效果不明显（尽管数据有限）。那些提供纵向评估的临床和临床前研究都揭示了关于皮质骨孔隙率的有力数据，并为未来的研究提供了基础。
