Sun Xiaoqiang, Li Chuting, Zhong Xue, Dong Daifeng, Ming Qingsen, Gao Yidian, Xiong Ge, Cheng Chang, Zhao Haofei, Wang Xiang, Yao Shuqiao
Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, China; Medical Psychological Institute of Central South University, Changsha 410011, Hunan, China; National Clinical Research Center for Mental Disorders.
Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, China; Department of Psychiatry, The First Affiliated Hospital of Sochoow University, Suzhou, Jiangsu, China.
Physiol Behav. 2020 Jun 1;220:112876. doi: 10.1016/j.physbeh.2020.112876. Epub 2020 Mar 16.
Variants of the serotonin transporter linked polymorphic region (5-HTTLPR) of the serotonin transporter gene SLC6A4 have been related with the onset of depression, anxiety, and other mental disorders. Homozygotes for the short 5-HTTLPR variant, referred to as the SS genotype, have greater cortisol responses to experimentally induced psychosocial stress. In the current study, we used functional magnetic resonance imaging (fMRI) to compare regional brain activations across 5-HTTLPR genotypes in subjects performing the Montreal Imaging Stress Task (MIST). Subjects with an SS genotype had significant greater increases in cortisol concentrations after the task than subjects with at least one long 5-HTTLPR allele. Additionally, relative to L carriers, the SS group had greater activation in the dorsomedial prefrontal cortex(dmPFC), dorsal anterior cingulate cortex, anterior insula.
血清素转运体基因SLC6A4的血清素转运体连锁多态性区域（5-HTTLPR）变体与抑郁症、焦虑症及其他精神障碍的发病有关。5-HTTLPR短变体的纯合子，即所谓的SS基因型，对实验诱导的心理社会应激具有更强的皮质醇反应。在本研究中，我们使用功能磁共振成像（fMRI）比较了执行蒙特利尔成像应激任务（MIST）的受试者中不同5-HTTLPR基因型的脑区激活情况。与至少携带一个5-HTTLPR长等位基因的受试者相比，SS基因型受试者在任务后皮质醇浓度显著升高。此外，相对于L等位基因携带者，SS组在背内侧前额叶皮质（dmPFC）、背侧前扣带回皮质、前岛叶有更强的激活。
