Postgraduate Program in Health Sciences and Technologies, Campus Faculty of Ceilandia, University of Brasilia, Brasilia 72220-275, Brazil.
Department of Pharmacy, Campus Faculty of Ceilandia, University of Brasilia, Brasilia 72220-275, Brazil.
Genes (Basel). 2020 Oct 26;11(11):1260. doi: 10.3390/genes11111260.
Major Depressive Disorder (MDD) is a disease that involves biological, psychological, and social interactions. Studies have shown the importance of genetics contribution to MDD development. The SCL6A4 protein (5HTTLPR) functions transporting serotonin, a neurotransmitter linked to mood and emotion, to the synaptic cleft. Hence, this study seeks, through a literature review, a better comprehension of the 5HTTLPR genetic variant association with MDD. For this purpose, a search was performed on the Virtual Health Library Portal for articles that related 5HTTLPR to MDD. Most of the articles found were conducted in the American continent, with one (1) study implemented in Brazil. 5HTTLPR associations were found regarding changes in the nervous system, pharmacology, and risk factors seen in MDD patients. When verifying the allelic distribution, the S allele had a higher frequency in most of the studies analyzed. Despite not finding a commonality in the different studies, the tremendous genetic variation found demonstrates the MDD complexity. For this reason, further studies in diverse populations should be conducted to assist in the understanding and treatment of the disease.
重度抑郁症（MDD）是一种涉及生物、心理和社会相互作用的疾病。研究表明，遗传学对 MDD 发展的贡献很重要。SCL6A4 蛋白（5HTTLPR）的功能是将与情绪和情感相关的神经递质 5-羟色胺转运到突触间隙。因此，本研究通过文献回顾，旨在更好地理解 5HTTLPR 基因变异与 MDD 的关联。为此，在虚拟健康图书馆门户上搜索了与 5HTTLPR 与 MDD 相关的文章。大多数发现的文章都在美国大陆进行，其中一项（1）研究在巴西进行。发现 5HTTLPR 与 MDD 患者的神经系统变化、药理学和风险因素有关。在验证等位基因分布时，大多数分析的研究中 S 等位基因的频率更高。尽管在不同的研究中没有发现共同性，但发现的巨大遗传变异表明 MDD 的复杂性。因此，应该在不同的人群中进行更多的研究，以帮助理解和治疗这种疾病。
