Porzio Rosa, Cordini Claudia, Rodolfi Anna Maria, Brigati Francesca, Ubiali Alessandro, Proietto Manuela, Di Nunzio Camilla, Cavanna Luigi
Department of Oncology and Hematology, Piacenza General Hospital, Piacenza I-29121, Italy.
Department of Pathology, Piacenza General Hospital, Piacenza I-29121, Italy.
Oncol Lett. 2020 Mar;19(3):2522-2526. doi: 10.3892/ol.2020.11329. Epub 2020 Jan 22.
Endometrial cancer (EC) represents the most frequently occuring gynecological tumor worldwide. The aim of the present study was to estimate the prognostic value of triple negative phenotype (TNP) in EC, and any associations with to pathological and clinical characteristics. The present study includes 220 cases of patients with EC who underwent to surgery at the Guglielmo da Saliceto Hospital of Piacenza (Italy) and the expressions of estrogen receptor (ER), progesterone receptor (PR) and oncoprotein c-erbB-2 (HER2) expression were examined. Pearson's Chi-square and Fisher's exact test were used to evaluate the association of TNP cases with variables associated with a worse prognosis. Progression-free survival (PFS) and overall survival (OS) were analyzed with Kaplan-Meier curves. A total of 26 patients (12%) had a TNP, and these cases had a higher percentage of high-risk histology, an advanced stage of disease at the time of diagnosis, with shorter PFS and OS when compared to non-TNP. The present study confirmed that TNP represents prognostic significance in EC.
子宫内膜癌（EC）是全球最常见的妇科肿瘤。本研究旨在评估三阴性表型（TNP）在子宫内膜癌中的预后价值，以及与病理和临床特征的任何关联。本研究纳入了220例在意大利皮亚琴察的古列尔莫·达·萨利切托医院接受手术的子宫内膜癌患者，并检测了雌激素受体（ER）、孕激素受体（PR）和癌蛋白c-erbB-2（HER2）的表达。采用Pearson卡方检验和Fisher精确检验来评估TNP病例与预后较差相关变量的关联。采用Kaplan-Meier曲线分析无进展生存期（PFS）和总生存期（OS）。共有26例患者（12%）为TNP，与非TNP患者相比，这些病例的高危组织学比例更高，诊断时疾病分期更晚，PFS和OS更短。本研究证实TNP在子宫内膜癌中具有预后意义。
