Department of Pathology, Department of Urology, University of Medicine and Pharmacy of Craiova, Romania;
Rom J Morphol Embryol. 2022 Jan-Mar;63(1):113-120. doi: 10.47162/RJME.63.1.11.
Endometrioid endometrial carcinomas (EECs) are the most common malignancies of the uterus. Hormonal dependence of EEC, in relation to biomolecular mechanisms involved in tumor progression, such as angiogenesis and cell proliferation, are aspects that can contribute to improving the prognosis of patients. We analyzed the immunoexpression of markers addressed to steroid hormone receptors [estrogen receptor (ER), progesterone receptor (PR)], angiogenesis [cluster of differentiation (CD)105∕endoglin] and cell proliferation (Ki-67) in 50 EECs related to the histopathological prognostic criteria of the lesions. In this study, the ER and PR scores were higher in low grade and early stages EEC, the statistical aspects being variable. The CD105 microvessel density and the Ki-67 proliferation index were superior in high grade and advanced stages EEC, the statistical aspects being significant or at the limit of significance. The ER∕PR and CD105∕Ki-67 immunomarker groups indicated a positive linear intragroup relation and a negative linear intergroup relation, suggesting the presence of synergistic and antagonistic molecular mechanisms of tumor endometrial control that can be used to stratify patients for targeted therapy.
子宫内膜样腺癌（EEC）是最常见的子宫恶性肿瘤。EEC 对激素的依赖性，以及涉及肿瘤进展的生物分子机制，如血管生成和细胞增殖，是可以改善患者预后的方面。我们分析了 50 例 EEC 中标记物的免疫表达，这些标记物针对甾体激素受体[雌激素受体（ER）、孕激素受体（PR）]、血管生成[分化群（CD）105/内格林]和细胞增殖（Ki-67），这些 EEC 与病变的组织病理学预后标准有关。在这项研究中，低级别和早期 EEC 的 ER 和 PR 评分较高，统计学方面是可变的。高级别和晚期 EEC 的 CD105 微血管密度和 Ki-67 增殖指数较高，统计学方面具有显著意义或接近显著意义。ER/PR 和 CD105/Ki-67 免疫标志物组表明存在正线性组内关系和负线性组间关系，提示存在协同和拮抗的肿瘤子宫内膜控制分子机制，可用于对患者进行靶向治疗分层。
