一目了然的癌与肉瘤微环境：我们所处的位置。
Carcinoma and Sarcoma Microenvironment at a Glance: Where We Are.
作者信息
Saggioro Mattia, D'Angelo Edoardo, Bisogno Gianni, Agostini Marco, Pozzobon Michela
机构信息
Stem Cells and Regenerative Medicine Lab, Fondazione Istituto di Ricerca Pediatrica Città Della Speranza, Padova, Italy.
Department of Women and Children Health, University of Padova, Padova, Italy.
出版信息
Front Oncol. 2020 Mar 3;10:76. doi: 10.3389/fonc.2020.00076. eCollection 2020.
Abstract
Cells and extracellular matrix (ECM) components represent the multifaceted and dynamic environment that distinguishes each organ. Cancer is characterized by the dysregulation of the composition and structure of the tissues, giving rise to the tumor milieu. In this review, we focus on the microenvironmental analysis of colorectal cancer (CRC) and rhabdomyosarcoma (RMS), two different solid tumors. While a lot is known about CRC environment, for RMS, this aspect is mostly unexplored. Following the example of the more complete CRC microenvironmental characterization, we collected and organized data on RMS for a better awareness of how tissue remodeling affects disease progression.
摘要
细胞和细胞外基质（ECM）成分构成了区分各个器官的多面且动态的环境。癌症的特征在于组织成分和结构的失调，从而产生肿瘤微环境。在本综述中，我们聚焦于两种不同实体瘤——结直肠癌（CRC）和横纹肌肉瘤（RMS）的微环境分析。虽然我们对CRC的环境了解很多，但对于RMS，这方面大多尚未被探索。以更完整的CRC微环境特征为范例，我们收集并整理了关于RMS的数据，以便更好地了解组织重塑如何影响疾病进展。
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