Department of Dermatology, The Second Affiliated Hospital, WanNan Medical College, Wuhu, China.
Department of Dermatology, Affiliated Provincial Hospital, University of Science and Technology of China, Hefei, China.
J Interferon Cytokine Res. 2020 Apr;40(4):172-181. doi: 10.1089/jir.2019.0012. Epub 2020 Mar 20.
Although the incidence of severe cutaneous adverse reactions (SCARs) is very low, if it is not diagnosed and treated in time, it can not only cause skin and mucous membrane involvement, but can also cause multiple organ failure and even death. The diagnostic criteria and treatment guidelines for severe drug eruptions have not been unified. Many medical centers have used human leukocyte antigen alleles to diagnose SCARs. Some prospective studies have shown that susceptibility gene testing can prevent SCARs as early as possible, but the widespread implementation of its technology is limited by being ethnically specific. With the unique advantages of cytokine detection technology, cytokines are increasingly important for the diagnosis and treatment of SCARs. Related cytokines/chemokines involved in the pathogenesis, adjuvant diagnosis, and treatment of SCARs are discussed.
虽然严重皮肤不良反应 (SCARs) 的发病率非常低，但如果不能及时诊断和治疗，不仅会导致皮肤和粘膜受累，还会导致多器官衰竭甚至死亡。严重药物反应的诊断标准和治疗指南尚未统一。许多医疗中心使用人类白细胞抗原等位基因来诊断 SCARs。一些前瞻性研究表明，易感基因检测可以尽早预防 SCARs，但由于种族特异性，其技术的广泛实施受到限制。随着细胞因子检测技术的独特优势，细胞因子在 SCARs 的诊断和治疗中越来越重要。讨论了与发病机制、辅助诊断和 SCARs 治疗相关的相关细胞因子/趋化因子。
