Yao Li-Min, Su Xia, Liu Li-Ling, Qi Yan-Ning, Wei Bo, Ma Ran, Du Xiao-Qing
Department of Dermatology and Venereology, Bethune International Peace Hospital, No. 398 of Zhongshan West Road, Qiaoxi District, Shijiazhuang, 050200, China.
Eur J Med Res. 2025 Jun 5;30(1):453. doi: 10.1186/s40001-025-02664-7.
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe disorders affecting the skin and mucous membranes, identified by low incidence but high mortality rates. Medications, particularly antibiotics, are the most common causative agents, and infection is also considered a common pathogenic factor. Multiple alleles diagnosed with drug allergies, which can help in predicting the occurrence of SJS and TEN were detected during research. Although the pathogenesis of SJS and TEN is not yet fully understood, the current gold standard for treatment involves early diagnosis and treatment, discontinuation of the allergenic drugs, and supportive care. Treatment options include systemic use of corticosteroids, intravenous immunoglobulin, cyclosporine A, plasmapheresis, and TNF-α inhibitors.
史蒂文斯-约翰逊综合征（SJS）和中毒性表皮坏死松解症（TEN）是影响皮肤和黏膜的严重疾病，发病率低但死亡率高。药物，尤其是抗生素，是最常见的致病因素，感染也被认为是常见的致病因素。在研究过程中检测到多个被诊断为药物过敏的等位基因，这有助于预测SJS和TEN的发生。尽管SJS和TEN的发病机制尚未完全明确，但目前的治疗金标准包括早期诊断和治疗、停用致敏药物以及支持性护理。治疗选择包括全身性使用皮质类固醇、静脉注射免疫球蛋白、环孢素A、血浆置换和肿瘤坏死因子-α抑制剂。
