Morzorati S, Lamishaw B, Lumeng L, Li T K, Bemis K, Clemens J
Department of Psychiatry, Indiana University School of Medicine, Indianapolis 46223.
Brain Res Bull. 1988 Jul;21(1):101-4. doi: 10.1016/0361-9230(88)90124-4.
Low dose ethanol has been shown to differentially affect the behavior of alcohol-preferring (P) and -nonpreferring (NP) rats. The present study was undertaken to determine if this differential effect is reflected in the EEG of these two rat lines. Frontocortical and hippocampal EEG were recorded from P and NP rats after intragastric infusions of ethanol (0.5 g/kg) and vehicle. Spectra were created from sequential 8-second epochs and power was calculated for frequency bands 0-4, 4-8, 8-16 and 16-50 Hz. Band power data was then grouped according to the rat's behavior and compared for P and NP rats. During nonREM sleep, ethanol produced a persistent increase in power in the NP rats, while power in the P rats was initially decreased, then returned to baseline. This differential effect was seen at both recording sites. The results suggest the P rats were midly aroused by low dose ethanol, while the NP rats were mildly sedated.
低剂量乙醇已被证明对嗜酒（P）和不嗜酒（NP）大鼠的行为有不同影响。本研究旨在确定这种差异效应是否在这两种大鼠品系的脑电图中有所体现。在给P和NP大鼠灌胃乙醇（0.5 g/kg）和赋形剂后，记录额叶皮质和海马的脑电图。从连续8秒的时间段创建频谱，并计算0-4、4-8、8-16和16-50 Hz频段的功率。然后根据大鼠的行为对频段功率数据进行分组，并对P和NP大鼠进行比较。在非快速眼动睡眠期间，乙醇使NP大鼠的功率持续增加，而P大鼠的功率最初下降，然后恢复到基线水平。在两个记录部位均观察到这种差异效应。结果表明，低剂量乙醇使P大鼠轻度兴奋，而使NP大鼠轻度镇静。
