支持基础化学毒理学研究以指导医学对策开发：美国国立卫生研究院化学对策研究计划。
Supporting Fundamental Chemical Toxicology Research To Inform Medical Countermeasure Developments: The National Institutes of Health Chemical Countermeasures Research Program.
作者信息
Yeung David T, Harper Jill R, Platoff Gennady E
机构信息
Department of Health and Human Services, National Institute of Allergy and Infectious Diseases/National Institutes of Health (NIAID/NIH), Bethesda, Maryland 20892, United States.
出版信息
Chem Res Toxicol. 2020 Apr 20;33(4):855-859. doi: 10.1021/acs.chemrestox.0c00086. Epub 2020 Mar 20.
Abstract
A high-consequence chemical emergency is a major public health concern. In the United States, the National Institute of Allergy and Infectious Diseases within the National Institutes of Health pioneers discovery and early development of critical medical countermeasures against chemical threats.
摘要
高后果化学紧急情况是一个重大的公共卫生问题。在美国，国立卫生研究院下属的国家过敏和传染病研究所率先开展针对化学威胁的关键医学应对措施的发现和早期研发工作。
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Toxicol Sci. 2015 Jan;143(1):178-84. doi: 10.1093/toxsci/kfu225. Epub 2014 Oct 20.
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