Zur Eyal
Compounding Solutions, Israel.
Int J Pharm Compd. 2020 Mar-Apr;24(2):104-108.
Although pilocarpine hydrochloride tablets are currently indicated for the treatment of xerostomia, their adverse effects are frequently reported. The development of a new, low-dose pilocarpine solution for topical oral-cavity use is needed. This article discusses a few clinical trials to formulate a topical low-dose solution of pilocarpine hydrochloride for the treatment of xerostomia and presents two low dose, stable formulations of pilocarpine topical spray that can improve the patient's quality of life with minimal adverse effects.
尽管目前盐酸毛果芸香碱片被用于治疗口腔干燥症，但其不良反应却屡有报道。因此，需要开发一种新的低剂量毛果芸香碱口腔局部用溶液。本文讨论了一些临床试验，以配制用于治疗口腔干燥症的低剂量盐酸毛果芸香碱局部用溶液，并展示了两种低剂量、稳定的毛果芸香碱局部喷雾剂配方，它们能以最小的不良反应改善患者的生活质量。
