Proteases and Tissue Remodeling Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, U.S.A.
Biochem Soc Trans. 2020 Apr 29;48(2):517-528. doi: 10.1042/BST20190675.
Cleavage of proteins in the extracellular milieu, including hormones, growth factors and their receptors, ion channels, and various cell adhesion and extracellular matrix molecules, plays a key role in the regulation of cell behavior. Among more than 500 proteolytic enzymes encoded by mammalian genomes, membrane-anchored serine proteases (MASPs), which are expressed on the surface of epithelial cells of all major organs, are excellently suited to mediate signal transduction across the epithelia and are increasingly being recognized as important regulators of epithelial development, function, and disease [ 1-3]. In this minireview, we summarize current knowledge of the in vivo roles of MASPs in acquisition and maintenance of some of the defining functions of epithelial tissues, such as barrier formation, ion transport, and sensory perception.
细胞外环境中蛋白质的裂解在细胞行为的调节中起着关键作用，包括激素、生长因子及其受体、离子通道和各种细胞黏附和细胞外基质分子。在哺乳动物基因组编码的 500 多种蛋白水解酶中，膜锚定丝氨酸蛋白酶（MASPs）表达于所有主要器官的上皮细胞表面，非常适合介导上皮细胞间的信号转导，并且越来越被认为是上皮细胞发育、功能和疾病的重要调节因子[1-3]。在这篇综述中，我们总结了 MASPs 在体内获得和维持上皮组织某些特有功能（如形成屏障、离子转运和感觉感知）中的作用的最新知识。
