Biointerfaces Institute, Department of Chemical Engineering, University of Michigan, Ann Arbor, Michigan, USA.
Biointerfaces Institute, Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2020 Jul;12(4):e1625. doi: 10.1002/wnan.1625. Epub 2020 Mar 20.
Clinical translation of nanoparticle-based drug delivery systems is hindered by an array of challenges including poor circulation time and limited targeting. Novel approaches including designing multifunctional particles, cell-mediated delivery systems, and fabrications of protein-based nanoparticles have gained attention to provide new perspectives to current drug delivery obstacles in the interdisciplinary field of nanomedicine. Collectively, these nanoparticle devices are currently being investigated for applications spanning from drug delivery and cancer therapy to medical imaging and immunotherapy. Here, we review the current state of the field, highlight opportunities, identify challenges, and present the future directions of the next generation of multifunctional nanoparticle drug delivery platforms. This article is categorized under: Biology-Inspired Nanomaterials > Protein and Virus-Based Structures Nanotechnology Approaches to Biology > Nanoscale Systems in Biology.
基于纳米粒子的药物输送系统的临床转化受到一系列挑战的阻碍，包括循环时间差和靶向性有限。新方法包括设计多功能粒子、细胞介导的输送系统和基于蛋白质的纳米粒子的制造，这些方法引起了人们的关注，为纳米医学这一跨学科领域中的当前药物输送障碍提供了新的视角。总的来说，这些纳米粒子装置目前正在被研究用于从药物输送和癌症治疗到医学成像和免疫治疗等各个领域。在这里，我们回顾了该领域的现状，强调了机遇，确定了挑战，并提出了下一代多功能纳米粒子药物输送平台的未来发展方向。本文属于以下分类：生物启发的纳米材料 > 基于蛋白质和病毒的结构 纳米技术在生物学中的应用 > 生物学中的纳米尺度系统
