Hannerz J
Department of Neurology, Karolinska Hospital, Stockholm, Sweden.
Cephalalgia. 1988 Dec;8(4):255-63. doi: 10.1046/j.1468-2982.1988.0804255.x.
Orbital venous vasculitis has been suggested to cause characteristic periorbital pain in patients with pathologic changes in their orbital phlebograms. The orbital pain is characterized by being unilateral, not shifting side, boring and pressing, but not throbbing, increasing on eye strain, exposure to cold, or weather changes, and resistant to analgesics. It is ameliorated by steroids. Fifty patients with symptoms of orbital venous vasculitis were investigated for other symptoms that could be related to the vasculitis. When the 32 female patients were compared with a randomly selected age- and sex-matched control group, there was a significant increase of symptoms of chronic fatigue, cold feet, gut problems such as constipation and/or diarrhea, arthralgia, memory impairment, rotatory vertigo, spontaneous ecchymoses (all, p less than 0.0001), back pain (p less than 0.012), and thrombophlebitis (p less than 0.022) in the patient group. These symptoms, although commonly occurring, seem in these patients to be related to the vasculitis. Blood tests of the fifty patients showed signs of inflammation which did not disagree with the hypothesis of an immunologic cause of the orbital venous vasculitis.
有人提出，眼眶静脉血管炎会在眼眶静脉造影有病理改变的患者中引发典型的眶周疼痛。眼眶疼痛的特点为单侧性、不换侧、呈钻痛和压痛而非搏动性痛，在用眼疲劳、受寒或天气变化时加重，且对镇痛药有抵抗性，使用类固醇可使其缓解。对50例有眼眶静脉血管炎症状的患者进行了调查，以查找可能与血管炎相关的其他症状。将32例女性患者与随机选取的年龄和性别匹配的对照组进行比较时，患者组中慢性疲劳、脚冷、便秘和/或腹泻等肠道问题、关节痛、记忆障碍、旋转性眩晕、自发性瘀斑（所有这些，p均小于0.0001）、背痛（p小于0.012）和血栓性静脉炎（p小于0.022）的症状显著增多。这些症状虽然常见，但在这些患者中似乎与血管炎有关。对这50例患者的血液检查显示有炎症迹象，这与眼眶静脉血管炎的免疫病因假说相符。
