内分泌干扰化学物质及其在女性青春期的作用：当前证据综述。
Endocrine-Disrupting Chemicals and Their Effects during Female Puberty: A Review of Current Evidence.
机构信息
Neonatal Intensive Care Unit, Department of Medical and Surgical Sciences of the Mothers, Children and Adults, University of Modena and Reggio Emilia, via del Pozzo 71, 41124 Modena, Italy.
Post Graduate School of Paediatrics, Department of Medical and Surgical Sciences of the Mothers, Children and Adults, University of Modena and Reggio Emilia, via del Pozzo 71, 41124 Modena, Italy.
出版信息
Int J Mol Sci. 2020 Mar 18;21(6):2078. doi: 10.3390/ijms21062078.
Puberty is the process of physical changes between childhood and adulthood during which adolescents reach sexual maturity and become capable of reproduction. It is considered one of the main temporal windows of susceptibility for the influence of the endocrine-disrupting chemicals (EDCs). EDCs may act as single chemical agents or as chemical mixtures; they can be pubertal influencers, accelerating and anticipating the processing of maturation of secondary sexual characteristics. Moreover, recent studies have started to point out how exposure to EDCs during puberty may predispose to breast cancer later in life. In fact, the estrogen-mimicking endocrine disruptors (EEDs) may influence breast tissue development during puberty in two main ways: the first is the action on the proliferation of the breast stromal cells, the second concerns epigenetic mechanisms. The aim of this mini-review was to better highlight what is new and what is not completely known regarding the role of EDCs during puberty.
青春期是儿童期向成年期转变过程中的身体变化阶段，在此期间青少年达到性成熟并具备生殖能力。它被认为是内分泌干扰物 (EDC) 影响的主要时间窗口之一。EDC 可以作为单一化学物质或化学混合物发挥作用；它们可以是青春期促进剂，加速和提前成熟第二性征的发育过程。此外，最近的研究开始指出青春期暴露于 EDC 如何可能导致日后患乳腺癌。事实上，类雌激素内分泌干扰物 (EED) 可能通过两种主要方式影响青春期的乳腺组织发育：一是对乳腺基质细胞增殖的作用，二是涉及表观遗传机制。本篇迷你综述的目的是更好地强调关于青春期 EDC 作用的新发现和尚未完全明确的内容。
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