Scsukova Sona, Rollerova Eva, Bujnakova Mlynarcikova Alzbeta
Institute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, Dubravska cesta 9, 845 05 Bratislava, Slovakia.
Department of Toxicology and Faculty of Medicine, Faculty of Public Health, Slovak Medical University, Limbova 12, 833 03 Bratislava, Slovakia.
Reprod Biol. 2016 Dec;16(4):243-254. doi: 10.1016/j.repbio.2016.09.001. Epub 2016 Sep 28.
A growing body of evidence suggests that exposure to chemical substances designated as endocrine disrupting chemicals (EDCs) due to their ability to disturb endocrine (hormonal) activity in humans and animals, may contribute to problems with fertility, pregnancy, and other aspects of reproduction. The presence of EDCs has already been associated with reproductive malfunction in wildlife species, but it remains difficult to prove causal relationships between the presence of EDCs and specific reproductive problems in vivo, especially in females. On the other hand, the increasing number of experiments with laboratory animals and in vitro research indicate the ability of different EDCs to influence the normal function of female reproductive system, and even their association with cancer development or progression. Research shows that EDCs may pose the greatest risk during prenatal and early postnatal development when organ and neural systems are forming. In this review article, we aim to point out a possible contribution of EDCs to the onset and development of female reproductive disorders and endocrine-related cancers with regard to the period of exposure to EDCs and affected endpoints (organs or processes).
越来越多的证据表明，接触因能够干扰人类和动物内分泌（激素）活动而被指定为内分泌干扰化学物质（EDC）的化学物质，可能会导致生育、怀孕及其他生殖方面的问题。EDC的存在已与野生动物物种的生殖功能障碍有关，但要证明EDC的存在与体内特定生殖问题之间的因果关系仍然很困难，尤其是在雌性动物中。另一方面，越来越多的实验动物实验和体外研究表明，不同的EDC有能力影响雌性生殖系统的正常功能，甚至它们与癌症的发生或发展有关。研究表明，在产前和产后早期发育阶段，当器官和神经系统正在形成时，EDC可能构成最大风险。在这篇综述文章中，我们旨在指出EDC在接触EDC的时期和受影响的终点（器官或过程）方面，对女性生殖障碍和内分泌相关癌症的发生和发展可能产生的影响。
