Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Cell Immunol. 2020 May;351:104087. doi: 10.1016/j.cellimm.2020.104087. Epub 2020 Mar 12.
Nonhuman primates (NHP) are important pre-clinical models for evaluation of the safety and efficacy of the most promising potential therapeutic advances in organ transplantation based on rodent studies. Although rare, dendritic cells (DC) play important roles in preservation of self tolerance and DC with immunoregulatory properties (regulatory DC; DCreg) can promote transplant tolerance in rodents when adoptively transferred to allograft recipients. NHP DCreg can be generated ex vivo from bone marrow precursors or blood monocytes of cynomolgus or rhesus macaques or baboons. NHP DCreg generated in the presence of anti-inflammatory factors that confer stability and resistance to maturation, subvert alloreactive T cell responses. When infused into rhesus renal allograft recipients before transplant, they safely prolong MHC mis-matched graft survival, associated with attenuation of anti-donor immune reactivity. In this concise review we describe the properties of NHP DCreg and discuss their influence on T cell responses, alloimmunity and organ transplant survival.
非人灵长类动物（NHP）是评估基于啮齿动物研究的最有前途的潜在治疗器官移植进展的安全性和疗效的重要临床前模型。虽然罕见，但树突状细胞（DC）在维持自身耐受方面发挥着重要作用，具有免疫调节特性的 DC（调节性 DC；DCreg）在同种异体移植物受者中过继转移时可促进移植耐受。NHP DCreg 可以从食蟹猴或恒河猴或狒狒的骨髓前体或血液单核细胞中体外产生。在赋予稳定性和抗成熟性的抗炎因子存在下产生的 NHP DCreg 会颠覆同种反应性 T 细胞反应。当在移植前输注到恒河猴肾移植受者中时，它们安全地延长了 MHC 错配移植物的存活时间，同时减弱了对供体的免疫反应性。在这篇简明的综述中，我们描述了 NHP DCreg 的特性，并讨论了它们对 T 细胞反应、同种异体免疫和器官移植存活的影响。
