Department of Mental Health, Parc Taulí Hospital Universitari, Institut d'Investigació i Innovació Parc Taulí (I3PT), Sabadell, Spain; Department of Clinical Sciences, Universitat de Barcelona, Barcelona, Spain.
Department of Mental Health, Parc Taulí Hospital Universitari, Institut d'Investigació i Innovació Parc Taulí (I3PT), Sabadell, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Carlos III Health Institute, Spain; Department of Psychiatry and Legal Medicine, Universitat Autònoma de Barcelona, Spain.
Prog Neuropsychopharmacol Biol Psychiatry. 2020 Jul 13;101:109929. doi: 10.1016/j.pnpbp.2020.109929. Epub 2020 Mar 18.
Hypothalamic-pituitary-adrenal (HPA) axis dysregulation and cognitive deficits are two well-characterized endophenotypes present in different serious mental illnesses (SMIs), including major depressive disorder, bipolar disorder and schizophrenia. Our aim was to study the influence of genetic and epigenetic variations in HPA axis-related genes on cognitive performance in clinical samples, including patients with major mood disorders and schizophrenia. A systematic search was performed using PubMed (Medline), PsycINFO and Scopus databases. The systematic review identified 12 studies dealing with HPA-related genes and cognition in samples including patients with SMIs, focusing on single nucleotide polymorphism (SNP) variants, while no studies analysing epigenetic variations were found. The results suggest different and specific effects on the cognitive performance of SNP variants in the HPA axis-related genes studied, as well as interactions with traumatic experiences. There was high heterogeneity in the studied samples, genes analysed, and cognitive tasks evaluated. The relationship between HPA-related genes and cognition in SMIs is still largely unknown, and further studies including larger samples and epigenetic variations are needed.
下丘脑-垂体-肾上腺 (HPA) 轴失调和认知缺陷是不同严重精神疾病 (SMI) 中两个特征明显的内表型，包括重性抑郁障碍、双相情感障碍和精神分裂症。我们的目的是研究 HPA 轴相关基因的遗传和表观遗传变异对临床样本中认知表现的影响，包括重性情绪障碍和精神分裂症患者。使用 PubMed (Medline)、PsycINFO 和 Scopus 数据库进行了系统搜索。系统评价确定了 12 项研究，这些研究涉及包括 SMI 患者在内的样本中的 HPA 相关基因和认知，重点是单核苷酸多态性 (SNP) 变异，而没有发现分析表观遗传变异的研究。结果表明，HPA 轴相关基因中的 SNP 变异对认知表现有不同的特定影响，并且与创伤经历存在相互作用。研究样本、分析的基因和评估的认知任务存在高度异质性。SMI 中 HPA 相关基因与认知之间的关系仍知之甚少，需要进一步研究包括更大样本和表观遗传变异的研究。
