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精神分裂症、双相情感障碍或重度抑郁症患者儿茶酚-O-甲基转移酶表达与认知功能的关联分析

Association Analysis Between Catechol-O-Methyltransferase Expression and Cognitive Function in Patients with Schizophrenia, Bipolar Disorder, or Major Depression.

作者信息

Ni Peiyan, Liu Manli, Wang Dequan, Tian Yang, Zhao Liansheng, Wei Jinxue, Yu Xueli, Qi Xueyu, Li Xiaojing, Yu Hua, Ni Rongjun, Ma Xiaohong, Deng Wei, Guo Wanjun, Wang Qiang, Li Tao

机构信息

The Psychiatric Laboratory, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic of China.

Mental Health Center, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic of China.

出版信息

Neuropsychiatr Dis Treat. 2021 Feb 22;17:567-574. doi: 10.2147/NDT.S286102. eCollection 2021.

DOI:10.2147/NDT.S286102
PMID:33654399
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7910219/
Abstract

INTRODUCTION

Schizophrenia, bipolar disorder (BD), and major depressive disorder are three common mental disorders. Although their diagnosis and treatment differ, they partially overlap.

METHODS

To explore the similarities and characteristics of these three psychiatric diseases, an intelligence quotient (IQ) assessment was performed to evaluate cognitive deficits. Relative catechol-O-methyltransferase () expression in peripheral blood mononuclear cells was examined in all three groups compared with healthy controls (HCs).

RESULTS

The results indicated that patients with any of the three psychiatric diseases presented IQ deficits, and that the first-episode schizophrenia (FES) group had even lower cognitive function than the other two groups. The relative expression decreased in the FES group and increased in the BD group compared with the HC group. The correlation analysis of expression level and IQ scores showed a positive correlation between relative expression and full-scale IQ in the HC group. However, this correlation disappeared in all three psychiatric diseases studied.

CONCLUSION

In conclusion, this cross-disease strategy provided important clues to explain lower IQ scores and dysregulated expression among three common mental illnesses.

摘要

引言

精神分裂症、双相情感障碍（BD）和重度抑郁症是三种常见的精神障碍。尽管它们的诊断和治疗有所不同，但存在部分重叠。

方法

为探究这三种精神疾病的相似性和特征，进行了智商（IQ）评估以评估认知缺陷。与健康对照（HCs）相比，检测了所有三组外周血单核细胞中儿茶酚-O-甲基转移酶（）的相对表达。

结果

结果表明，这三种精神疾病中的任何一种患者均存在智商缺陷，且首发精神分裂症（FES）组的认知功能甚至低于其他两组。与HC组相比，FES组的相对表达降低，BD组的相对表达增加。表达水平与智商分数的相关性分析显示，HC组中相对表达与全量表智商呈正相关。然而，在所有三种研究的精神疾病中，这种相关性均消失。

结论

总之，这种跨疾病策略为解释三种常见精神疾病中较低的智商分数和表达失调提供了重要线索。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a26a/7910219/b7abc1a2680c/NDT-17-567-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a26a/7910219/b7abc1a2680c/NDT-17-567-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a26a/7910219/b7abc1a2680c/NDT-17-567-g0001.jpg

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